Deficiency
Night blindness, xerophthalmia
What is vitamin A?
This tumor suppressor gene mutation is associated with multiple endocrine neoplasia type 2.
What is RET?
This class of antibiotics function by blocking DNA gyrase and topoisomerase.
What are fluoroquinolones?
Patient very soon after a gastric sleeve is leaking. Where, and why?
Near the GE jxn, primarily related to mechanics associated with increased pressure at the proximal staple line.
Gallbladder cancer
What is T2? And what is management?
T1B = tumor into muscular layer
T2 = tumor into perimuscular tissue
Both require chole, extended hepatic resection, portal LAD, possible bile duct resection for margins
Poor wound healing, alopecia, dermatitis
What is zinc?
This gene mutation maybe seen in individuals with hamartomatous polyps throughout the GI tract and spots around their mouth.
What is STK11 (LKB1)? Peutz Jeghers
The most common side effects / (the side effects absite will test) of tacrolimus.
What is neurotoxicity and nephrotoxicity? Tremors...
Patient has a splenectomy and then gets an OPSI. Yikes. What 3 organisms maybe responsible?
Neisseria meningitidis
H Flu
S pneumo
Chemotherapeutic drug utilized in high risk adrenal cancers.
What is mitotane?
-destroys zona fasciculata and reticularis and inhibits steroid synthesis
Refractory hypokalemia, arrhythmias, muscle spasms
What is magnesium?
This gene is associated with hereditary gastric cancer.
What is Cdh1?
The reversal agent for heparin carries a significant side effect of...
What is hypotension? (2/2 protamine)
Pediatric patient... post–Hirschsprung pull-through child who is toilet trained BUT still soils daily. Why?
Overflow liquid stool from chronic constipation.
Amplification of this oncogene in a child with an adrenal mass predicts aggressive disease and poor prognosis regardless of stage.
What is n-myc?
-neuroblastoma
-neural crest tumor SNS
-paraneoplastic opsoclonus–myoclonus, increased catecholamines, abd mass that crosses midline
1) Insulin resistance
2) Refractory hyperglycemia despite insulin
3) Peripheral neuropathy (rare)
What is chromium?
A patient has medullary thyroid cancer, pheochromocytoma, and hyperparathyroidism. What must be addressed FIRST?
Pheochromocytoma → adrenalectomy first
This transplant immunosuppressant inhibits inosine monophosphate dehydrogenase, blocks de novo purine synthesis, and preferentially affects T and B lymphocytes.
What is mycophenolate mofetil?
Patient is started on heparin pre op... on day 7 platelets go from 200,000 to 20,000. What are the screening and confirmatory tests for the suspected diagnosis?
Screening test = platelet factor 4 (high sensitivity)
Confirmatory = serotonin release assay
0.5 cm appendiceal adenoCA at the tip. Next step?
Right hemicolectomy.
Adenocarcinoma, NOT carcinoid!
1) Cardiomyopathy (dilated, heart failure)
2) Skeletal muscle weakness
3) Immune dysfunction
Can be seen in those on TPN
What is selenium?
A 30-year-old develops breast cancer and later a soft-tissue sarcoma. And then gets leukemia. What gene is involved?
What is TP53?
Li Fraumeni
This monoclonal antibody targets the IL-2 receptor (CD25) and is commonly used for induction immunosuppression in solid-organ transplantation.
What is basiliximab?
A patient on POD 5 after a B2 gastrectomy develops sudden tachycardia, fever, and signs of sepsis. CT shows free fluid / air. What is going on?
Duodenal stump blowout.
Management of 2 cm rectal carcinoid with no lymphovascular invasion?
> 2 cm = LAR or APR along with mesorectal excision
< 1 cm = local excision
1-2 cm = depends on high or low risk factors (submucosal, lymphovascular invasion, exc...)