Nonmalig. Disorders
Neoplasms I
Neoplasms II
Myeloproliferatives
Myelodysplastics
100
This disorders is characterized by a defect in sphingomyelinase, which results in macrophages with a foamy appearance
What is Niemann-Pick Disease
100
This term describes an abundance of blasts and some mature forms with an apparent decrease in the intermediate maturational stages
What is Leukemic Hiatus
100
This stain differentiates between myelocytic and monocytic cell lines
What is esterase stains specific esterase (chloroacetate esterase) = + myeloblasts, - monoblasts non-specific esterase (alpha-napthyl acetate esterase) = + monoblasts, - myeloblasts
100
Pruritis after bathing is associated with this disease state
What is Polycythemia Vera
100
The 5q-syndrome frequently shows dysplasia in this cell lineage
What is Megakaryocytic
200
This benign anomaly, caused by mucopolysaccharide degradation, is morphologically similar to toxic granulation
What is Alder-Reilly Anomaly
200
This form of leukemia is often positive for tartrate-resistant acid phosphatase (TRAP)
What is Hairy Cell Leukemia
200
Neoplastic lymphoid cells and erythroleukemia show block positivity when this special stain is applied
What is PAS (Periodic Acid Schiff)
200
This disease is highly associated with hypocellular bone marrow with fibrotic features
What is Myelofibrosis with Myeloid Metaplasia (aka Chronic Idiopathic Myelofibrosis)
200
The chromosomal abnormalities present in most cases of MDS are located on these chromosomes
What is 5, 7, 8
300
This benign condition has the following characteristics: WBC count 53 × 109/L, left shift, occurred in response to an inflammatory process
What is Leukemoid Reaction
300
A routine CBC from a 5-year-old boy shows 90% blasts in peripheral circulation. Cytochemical staining with MPO and SBB was negative. Based on these findings, the patient is suffering from this condition.
What is Acute Lymphocytic Leukemia
300
Name This Disease: 73 year old man, 65% Blast count myeloperoxidase + Sudan black B + Specific esterase + N/S esterase + Tdt -
What is Acute Myelomonocytic Leukemia
300
Name This Disease: A patient visits his family physician with complaints of vague malaise with an insidious onset. The physician orders a CBC and obtains the following results: Blasts: 3% Myelocytes: 10% Metamyelocytes: 22% Bands: 15% Neutrophils: 40% Lymphocytes: 6% Basophils: 2% Monocytes: 2% Based off of those results, the physician orders a LAP which shows a score of 6.
What is Chronic Myelocytic Leukemia (CML)
300
Name This Disease: 55 year old male with bicytopenia, 1% blasts in BM, dysplasia in 30% of cells in both myeloids and erythroids, 11% ringed sideroblasts
What is Refractory Anemia with Multilineage Dysplasia
400
This feature helps to differentiate the lymphocytes of infectious mono from those found in neoplastic lymphocytic disorders
What is Lymphs are morphologically similar in neoplasms
400
What classification, according to the WHO system, does a 19-year old with precursor B-cell leukemia belong to?
What is Acute Lymphocytic Leukemia (ALL)
400
These three therapy phases for chemo are utilized for most leukemias
What is Induction Therapy, Maintenance Therapy, Consolidation Therapy
400
Name This Disease: A 45 year old male enters the ER with thrombosis of the leg. The attending physician orders a CBC, LAP, and performs a bone marrow biopsy. The laboratory findings are as follows: *Platelets markedly increased *WBC 15,000 x 103/uL *RBC 5.1 x 1012/L *LAP 85 *Increased megakaryocytes in bone marrow with abnormal morphology
What is Essential Thrombocythemia
400
Name 5 dysplastic changes associated with Red or White cells or precursors in myelodysplastic disease
What is: Giant, multinucleated RBC precursors Nuclear fragmentation Nuclear budding Abnormal nuclear shapes Karryohexis Abnormal staining of primary granules in pros and myelos Micromegakaryocytes
500
Name This Disease: 11 year old boy with many recurrent infections due to ineffective respiratory burst oxidase system. Nitroblue tetrazolium slide test (NBT) was positive.
What is Chronic Granulomatous Disease
500
Fill in the blanks: FAB Classification of Neoplasms M0 ___________________ M1 ___________________ M2 ___________________ M3 ___________________ M4 ___________________ M5 ___________________ M6 ___________________ M7 ___________________
What is: M1 = Acute myeloblastic leukemia WITHOUT DIFFERENTIATION M1 = Acute myeloblastic leukemia WITH MINIMAL DIFFERENTIATION M2 = Acute Myeloblastic leukemia WITH MATURATION M3 = Acute Promyelocytic leukemia M4 = Acute Myelomonocytic leukemia M5 = Actue Monoblastic leukemia M6 = Acute Erythroleukemia M7 = Megakaryocytic leukemia
500
A cancer patient with negative traditional tests with a remaining positive molecular test is termed as having this...
What is Minimum Residual Disease (MRD)
500
Name This Disease: 70 year old female, 120 x 103/uL WBC, mature cells found on manual differential, increased LAP score, Philadelphia chromosome absent
What is Chronic Neutrophilic Leukemia
500
What is the IPSS score and associated prognosis for the following myelodysplastic disorder? 3 cytopenias 14% BM Blasts Complex karyotype (>2 abnormalities)
What is IPSS score of 3, Poor prognosis (high risk of fatality in <2 years)
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