Mechanism and Monitoring
Safety and REMS
Patient and HCP Education
Payer and Access Literacy
Program Operations and Compliance
Cytokinetics and aficamten Basics
100

This medicine works by relaxing the heart muscle through myosin inhibition.

What is aficamten (MYQORZO)?

100

This safety program helps ensure MyQorzo is used and monitored correctly.

What is the REMS program?

100

In obstructive HCM, this part of the heart is too thick, making it harder for blood to exit.

What is the left ventricle?

100

This is your insurance company’s list of covered medicines.

What is a formulary?

100

Navigators can educate, but cannot do this about patient dosing.

What is give medical advice?

100

Cytokinetics develops medicines that target this kind of body tissue.

What is muscle tissue?

200

Reducing how hard the heart squeezes helps lower this type of pressure that blocks blood flow.

What is the LVOT gradient?

200

A patient reports new dizziness and shortness of breath — the navigator’s next step is to do this.

What is advise the patient to let the HCP now immediately?

200

Mild tiredness is common, but chest pain or fainting should make the patient do this.

What is alert the HCP immediately?

200

When the insurance wants proof before paying for a medicine, it’s called this.

What is prior authorization?

200

Teaching patients about options is allowed but pushing them toward one choice breaks this.

What is compliance or scope of practice?

200

MyQorzo is approved for adults with this specific type of HCM.

What is obstructive HCM?

300

Patients on aficamten need these regular tests to check heart strength and safety.

What are echocardiograms?

300

MyQorzo should be used carefully in patients with this type of heart failure.

What is reduced ejection fraction (LVEF <50%)?

300

When asked for dosing advice, navigators should do this instead of giving an answer.

What is refer them to their prescriber?

300

This policy means a patient must try a cheaper drug before the insurer covers another.

What is step therapy? 

300

This short phrase reminds navigators to keep notes professional, accurate, and within guidelines.

What is "if it wasn't documented, it didn't happen?"

300

This is the main goal of MyQorzo therapy in patients with oHCM.

What is to reduce obstruction and improve symptoms?

400

If a patient’s pumping strength (LVEF) drops too low, this should happen to the dose.

What is holding or lowering the dose?

400

MyQorzo requires ongoing checks because it can affect how strongly the heart does this.

What is contract or pump blood?

400

A caring statement like “I know this can feel like a lot — let’s take it step by step” shows this quality.

What is empathy?

400

This document looks like a bill but just explains what was paid by insurance.

What is Explanation of Benefits (EOB)?

400

This term describes staying within your professional role and avoiding clinical decision-making.  

What is scope of practice?

400

MyQorzo differs from traditional therapies like beta-blockers because it works directly on this part of the heart cell.

What is the cardiac myosin motor protein?

500

When the heart squeezes too strongly or has low blood volume, this kind of obstruction gets worse.

What is LVOT obstruction?

500

Because the safety of MyQorzo hasn’t been proven during pregnancy, navigators should remind patients to do this before starting treatment.

What is talk with their prescriber about pregnancy and birth control planning?

500

When a patient seems unsure after education, this is the best way for a navigator to double-check comprehension.

What is ask the patient to explain the information back in their own words?

500

This prescriber letter explains to insurance why a patient needs a specific therapy.

What is Letter of Medical Necessity?

500

Quality audits help ensure navigator notes are accurate and compliant. If an audit finds an error, the best professional response is this.

What is acknowledge the feedback, correct the mistake, and use it as a learning opportunity?

500

The name “MyQorzo” is inspired by this vital part of the body.

What is the heart (myocardium)?

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