Aging Targets
A central protein kinase that acts as the master nutrient, energy, and stress sensor of the cell
What is mTOR?
Cell permanently stops dividing but remains metabolically active
What is Senescence?
An advisor of the Aging Initiative. He is known for being eccentric and having a large white beard
Who is George Church?
Developing aging drugs for dogs. Raised $100M in Series C funding earlier this year led by age1
What is Loyal?
What do these stand for:
MAST
OASIS
CHIMES
NOVA
What is Muscle Aging Science Translation, Osteoarthritis Surgical Innovation and Science, Circadian Health Innovation in Medicine, Epidemiology and Sleep, Neuroscience of Vitality and Aging.
A stress-responsive hormone and cytokine in the TGF-β superfamily. Its receptor is GFRAL, and it is the primary biological driver of cachexia
What is GDF15?
When a single gene or allele controls multiple traits, producing beneficial effects early in life and detrimental effects later in life
What is Antagonistic Pleiotropy?
Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School. Specializes in antioxidant biology, the molecular basis of aging, rejuvenation, and lifespan control
Who is Vadim Gladyshev?
Founded in 2021 with $3 billion in early funding from prominent individuals such as Jeff Bezos.
What is Altos Labs?
Bodybuilder and YouTube influencer present at MAST
Jeff Nippard
An intracellular pattern-recognition receptor that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Actively being investigated for CNS and metabolic disorders
What is NLRP3?
Organisms age and die because of an evolutionary trade-off in how they spend limited energy
What is Disposable soma?
Pioneer in aging clocks and epigenetic biomarkers of aging. Formerly the Founding Principal Investigator at Altos Labs
Who is Steve Horvath?
Founded on September 18, 2013, and operates as an independent subsidiary of Alphabet Inc. Headed by CEO Arthur D. Levinson, the former CEO of Genentech and current chairman of Apple.
What is Calico Life Sciences?
The month and year that Ezekiel and Arthur joined the Aging Initiative
What is May 2025?
A Histone deacetylase that is predominantly found in the cytoplasm that primarily targets non-histone proteins
What is HDAC6?
Because each cell division carries a small, random chance of a DNA mutation, an organism with billions more cells or a much longer lifespan should, in theory, experience an overwhelmingly high lifetime incidence of cancer. However, an animal's overall cancer risk does not strongly correlate with its body size or total number of cells.
What is Peto's Paradox?
Who is Eric Verdin?
Uses a proprietary "pooled in-vivo screening" drug discovery platform to identify targets and therapies for complex age-related diseases. Named after a type of knot
What is Gordian Biotechnology?
Many individuals in the Aging Initiative frequent this place. It is named after a prominent city in Western Europe
Family of retrotransposons that make up approximately 17% of the human genome
What is LINE1?
Aging is not actively selected for as a functional trait; rather, it is the passive, accumulated side effect of unselected, late-acting deleterious mutations.
Medawar’s mutation-accumulation theory?
Professor of Cell Biology at Harvard Medical School, Co-Director of the Paul F. Glenn Center for Biology of Aging Research. She made fundamental contributions to our understanding of how mitochondria contribute to human health, aging, and diseases of aging
Who is Marcia Haigis?
Founded in 2019 and headquartered in New York, NY. Lead asset is an oral small-molecule AMPK Network Activator in clinical development for obesity and cardiometabolic disease.
Former Aging Initiative Queen and future Queen of NYC. Saty’s girlfriend
Himal Bamzai-Wokhlu