This agent was used in conjunction with prednisone as the historical standard of care for multiple myeloma patients who were deemed not transplant candidates
What is melphalan?
100
This agent is a CYP1A2 substrate and innteracts with agents such as ciprofloxacin and omeprazole
What is Bendamustine?
100
Dose limiting toxicity of alkylating agents.
What is myelosuppression
200
Derivative of mechlorethamine (nitrogen mustard) and undergoes spontaneous hydrolysis in the bloodstream to inert products
What is melphalan
200
This agent can be given intrathecally
What is thiotepa?
200
This agent is commonly given as either 120mg/m2 and 90mg/m2
What is bendamustine? 90mg/m2 is given with Rituxan.
200
Concentrations of this agent may be decrease phenytoin concentrations if given concomitantly.
What is BCNU?
200
Common delayed toxicity of alkylating agents
What is secondary malignacies?
300
Carmustine is an example of this class of alkylators
What is nitrosourea?
300
True of False: Busulfan PK monitoring is done for BuMelT, a common conditiong regimen prior to an autologous stem cell transplant for NHL.
What is False?
300
Minimum thiotepa at which dose which requires frequent showers is recommended
What is 250mg/m2?
300
True or False: Use of Tylenol should be limited beginning 72 hours prior to, during, and continuing until 48hrs post busulifan
What is TRUE
300
Skin changes is common with these alkylators
What are busulifan and thiotepa?
400
Busulifan is an example of this class of alkylating agents
What is Alkyl sulfonates
400
This is available as an injection and as 2mg tablets for BMT conditioning
What is busulfan?
400
These drugs need to adjusted for renal or hepatic dysfunction.
What are bendamustine, melphalan, carmustine (renal) and bendamustine (hepatic)?
400
Administration of this agent with Busulfan would result in a potential law-suit
What is metronidazole.
400
Ativan, phenytoin, and/or Keppra are used to prevent this toxicity when this agent crosses the blood brain barrier at high doses.
What are seizures (toxicity) and busulifan (agent)
500
Thiotepa is an example of this class of alkylating agents
What is ethylenimine?
500
Melphalan must be given within 1 hour of mixing because of this reason.
What is it undergoes spontaneous hydrolysis in bloodstream to inert products
500
Busulfan doses are adjusted to achieve this AUC when used in conditioning for CML-CP and this AUC for all other disease states
What is > 900 ng/ml (CML-CP) and 800-900 ng/ml (for all other disease states)?
500
Mechanism by which cyclophosphamide interacts with busulfan
What is glutathione depletion?
500
These methods are used to minimize mucositis and myelotoxicity when this agent is administered as a single agent in transplant conditioning agents.
What are cryotherapy for mucositis and amifostine for myelotoxicity (methods) and melphalan (agent)?