Hormone Pathways
Which thyroid hormone is more active: T3 or T4?
T3
Weight gain, cold intolerance, and constipation suggest which condition?
hypothyroidism
Low TSH and high free T4 indicates...?
primary hyperthyroidism
Which disease is caused by TSH-receptor stimulating antibodies?
Graves’ disease
Name a common treatment for Graves’ disease.
radioactive iodine (RAI) therapy
What enzyme converts T4 to T3 in peripheral tissues?
deiodinase
A patient with bulging eyes and tremors likely has...?
Graves’ disease
A patient has low TSH and low T4. What type of hypothyroidism is this?
secondary (central) hypothyroidism
This surgical procedure can lead to hypothyroidism.
thyroidectomy
Which drug inhibits thyroid peroxidase?
Carbimazole
Which protein predominantly transports thyroid hormones in the blood?
Thyroxine-binding globulin (TBG)
What symptom is shared by both hypo- and hyperthyroidism?
hair thinning/loss
What antibody is typically positive in Hashimoto’s thyroiditis?
anti-TPO (thyroid peroxidase antibody)
How is maternal Grave's disease transferred?
anti-TSHR antibodies
Which drug inhibits thyroid hormone synthesis and is safe in the 2nd/3rd trimesters?
Methimazole