Type 1 HS
This class of allergic disease commonly affects cats and can cause lesions like miliary dermatitis and rodent ulcers
What is eosinophilic granuloma complex
Almost all cats in the USA are this blood type
What is A
This is the veterinary species in which IgA nephropathy is found
What is dog
This is the immune cell type that is implicated in the development of type IV hypersensitivity
What is T cell
This interleukin is a major cause of itch in atopic dogs and is targeted by both apoquel (oclacitinib) and cytopoint (lokivetmab)
What is IL-31
Name the most common blood type that causes hemolytic disease of newborns in the horse
Aa, Qa
This complement component is most important in facilitating a localized type 3 HS reaction
What is C5a
This is the most common reason for false positive tuberculin skin tests in the cow, and can be mitigated by performing doing comparative skin testing
What is cross-reaction with m. avium
Name the first line drug for anaphylaxis and it's MOA (what class of drugs is it)
What is epinephrine, b and alpha agonist
Icterus, hemoglobinuria
This is the major antigen implicated in equine asthma (it's a vague one)
What is dust
This is the cell type that predominantly causes the "tubercle" in TB
What are macrophages
This molecule is found in the skin of allergic animals and can communicate DIRECTLY with neurons to produce itch, no immune stimulation needed
What is thymic stromal lymphoprotein (TSLP)
This is the most clinically relevant blood type in the dog
What is DEA 1.1
Deposits associated with type 1 membranoproliferative glomerulonephritis contain _____, whereas those associated with type 2 contain _____
Type 1: Immunoglobulin complexes (also some C3)
Type 2: C3, NO IG!
The ELIspot is a modified ELISA; what does it detect (antibodies for what are coated on the plate)?
What are CYTOKINES!
name 2 of the 3 species for whom BOTH the respiratory and intestinal tracts are (anaphylactic) shock organs
What are: pig, cat, horse
(dog is liver; the rest are just respiratory)Name 1 of the 3 mechanisms by which drugs can cause a type 2 hypersensitivity
-Drug can directly bind RBC surface glycoprotein (recognized as foreign; eliminated by Abs)
-Drug can alter RBC surface membrane; Abs passively adsorb RBCs
Name one etiologic agent (infectious) that causes purpura hemorrhagica in the horse
strep equi, coryne pseudotb, rhodococcus equi, EIV, EHV1
Name 3 cell types involved in causing allergic contact dermatitis
1. Langerhans cell captures the hapten/protein complex
2. Langerhans cytokines activate Th1 and Th17
3. They promote CTL activation
4. NK cells may also contribute