Medicine's Fight
In the Alzheimer's disease branch of neuroscience primarily using test-tube experiments, cell culture examination, epidemiological surveys, clinical trials, and psychological analyses based on social interaction over animal testing.
What is alternatives being used predominately over animal testing in Alzheimer's research?
The neuroimmune system either has no effect or increases the rate of brain death.
What is bodily response?
Arising tension on the relationship of the family members with the victim due to "burden" of responsibility of caring for the victim, ensuring that family members do not become clinically depressed or have great anxiety, and increased worry, confusion, and strain between the family members on how long to proceed.
What is effect on family?
The factor that lies in the hands of your vote, meaning what a national representative advocates for. Whether this includes changing the healthcare system to include free nursing homes and AD medications, or laws against reproduction if this genetic factor has been identified.
What is political?
Prevention includes, dna tests that can identify markers which indicate high probability of the disease and if tested positive refraining from reproduction, and understanding and avoiding factors that increase your likelihood of developing AD yourself. Such as, high blood pressure, poor diet and high cholesterol.
What is most effective solution to stopping the spread among humans?
The reasoning for the genetic mutations involved in ordering the overproduction of tau and beta-amyloid proteins, and the over-splicing of MAPT genes, why these mutations reoccur in different parts of the brain and spread, and finally the cause for the ineffective neuroimmune response.
What is inconclusive research (on causes and effects of bodily development and response)?
Repercussions of moderate Alzheimer's disease and other dementia's include memory loss ranging from loss of face recognition to loss of speech, reading and writing skills, inability to perform cognitive tasks from problem solving and thinking rationally to getting dressed, inability to experience or control emotion, and lack of control over body and mind. Additionally, for severe AD this includes seizures, complete cognitive failure, difficulty swallowing, and loss of motor functions.
What is effect/symptoms?
The factor that questions the duties and responsibilities of AD victims and their families regarding treatment and prevention. An example of this question type would be: Would it be ________ to end his suffering now?
What is moral/ethical?
To maintain mental function ensure a long-term healthy lifestyle. Meaning regular social interactions, constant exercise, and a specialised diet. This is etiology based therapy. Further therapies include, cognitive-behavioural therapy for mild Alzheimer's and nurturing cognitive function through communication skill upkeep and rational thinking practice through problem-solving (puzzles, sudoku, etc.).
What is treatments known to somewhat maintain mental function?
The neurodegenerative effects of Alzheimer's and the bodies response appearing throughout sections of the brain and then spreading out to finally meet each other and cover the majority of the brain. With particular speed of spread in the frontal lobe, the temporal lobe, and the parietal lobe.
What is progression?
As the genetically mutated cells "reproduce" and expand over the entire brain they encode an order to splice too many MAPT genes, to overproduce tau proteins, and to produce too many beta-amyloid proteins. (Oversimplified)
What is spread (within the brain)?
The inherited, traditions, beliefs, and expectations, pertaining to the knowledge base surrounding health. Such as, the acceptance of bad smoking and alcohol habits, or the disbelief in the effectivity of modern medications.
What is cultural?
The research proven remedies include acetylcholinesterase inhibitors for mild to moderate Alzheimer's symptoms and N-methyl D-aspartate receptor antagonists for severe AD. These have, supposedly, been provided in prescription drugs such as, donepezil for mild Alzheimer's, and galantamine and/or rivastigmine for severe Alzheimer's.
What is medications?
By blocking the interleukin-10 cytokine the neuroimmune response corrects itself from its previous destructive pattern and begins deconstructing the beta-amyloid plaques.
What is beneficial bodily response?
The only known mode of transmission amongst humans for Alzheimer's disease is genetic. The gene that indicates a high probability of AD is apolipoprotein E, the most dangerous strand of this gene being Apoe e4.
What is spread (amongst humans)?
Based on the wealth and gdp per capita of a nation which effects the standard lifestyle including exercise and fitness, diet, accessibility to medications, education level, and the necessary mental requirements for occupations.
What is economic?
With baseline clinical trials finished, immunotherapy, and a mechanism involving monoclonal antibodies that target the over-produced beta-amyloid proteins, which are the main modes for slowing the rate of symptom severity increase.
What is possible solutions to slowing the spread throughout the brain?
The neuroimmune system produces microglia which typically clear cells of harmful materials, but, as this process is activated by the beta amyloid protein which is being over-produced the micrologia cannot keep up at such a high rate of function and induce neuroinflammation which damages nerve cells and worsens cognitive abilities. Additionally, the leukocytes begin to express class 2 antigens which are fighting the immune response of the body.
What is harmful bodily response?
The splice of too many MAPT genes which makes them harmful, tau proteins gathering together making neurofibrillary tangles which block the passage of neurons and thus information, and beta-amyloid proteins forming plaques which further restrict messaging causing the neurodegenerative effects of AD all throughout the brain.
What is brain death/damage?
The main contributing factor, based on person-to-person interactions and standards, societal norms with education and stigmas surrounding seeking treatment.
What is social?