Peaks, troughs, and everything in between
Therapeutic peak value range of gentamicin/tobramycin in conventional dosing
What is 5-8 mg/L?
The specific gram stain of bacteria that aminoglycosides cover
What is gram negative bacteria?
The weight-based dosing for conventional dosing of gentamicin/tobramycin
What is 5-7 mg/kg/day Q8-12H? (i.e. 2 mg/kg/dose)
Hartford Nomogram is based off __ mg/kg dosing
What is 7 mg/kg?
The peak value of once daily dosing for gentamicin/tobramycin
What is 20 mg/L?
The ONLY indication that we can say aminoglycosides cover gram (+) infections
What is synergy use with beta-lactams?
The weight-based dosing for "once daily" dosing of gentamicin/tobramycin
5-7 mg/kg/day
The amount of hours (range) to measure a level after a dose based on Hartford Nomogram
What is 6-14 hours?
The time allowed to draw a peak after gentamicin infusion is given
What is 1 hour?
The desirable peak range for the use of pneumonia of gentamicin/tobramycin
What is 8-10 mg/L?
The ”spooky” MDR bug that aminoglycosides cover
What is pseudomonas aeruginosa?
What is 0.25 L/kg?
A patient receives 360 mg of gentamicin infusion 8 hours ago. The concentration came back to be 8.5 mg/L. Based on the Hartford Nomogram, this is the appropriate dosing interval.
What is 36 hours?
NP is receiving 140mg of gentamicin over 30 minutes every 8 hours. Vd is 17 L/kg. Elimination rate constant is 0.4 hr-1. This is her predicted peak plasma concentration at steady state
What is 5.75 mg/L?
The side effect that is associated with [trough] > 4 for > 10 days
What is ototoxicity?
Two common side effects of aminoglycosides
What is ototoxicity and nephrotoxicity?
We would use this infusion model for patients with good kidney function before we reach a steady state concentration
What is short infusion model?
A patient receives 720 mg of gentamicin infusion 12 hours ago. The concentration came back to be 10 mg/L. Based on the Hartford Nomogram, this is the appropriate dosing interval.
What is 48 hours?
MS, a 100kg man, is receiving tobramycin 5 mg/kg every 24 hours. His clearance is 6.5 L/hr. Vd is 16L. Elimination rate constant of 0.40625. This is his steady state peak concentration 1 hour after starting the 30 minute infusion
What is 23.1 mg/L?
This is the advantage of the once daily dosing (I.e. extended interval)
What is less ototoxicity and nephrotoxicity?
MW is a 27 year old male, SCr of 1.0, weighing 264 lbs. He is receiving gentamicin infusion 240mg every 24 hours. This dosing is categorized as _ dosing
What is conventional dosing?