Teaching
True or False: Take missed doses as soon as possible within 12 hrs of missed dose
True
What is Drug-Food Interaction was mentioned?
Hint: Juice!
Avoid grapefruit products
True or False: Does amlodipine cause flushing?
True
True or False: Amlodipine crosses placenta (Distribution)
True- crosses the placenta
True or False: this medication cures hypertension
False - this medication controls hypertension but does not cure it
The inhibition of which Cytochrome/enzyme causes amlodipine to increase in the blood
P450/CYP3A4
What are some Neuro side effects of amlodipine?
dizziness, fatigue.
What is the duration of action?
24 hours
True or False: Caution patient to stay in the same position to minimize orthostatic hypotension
False - caution patient to SLOWLY switch positions to minimize orthostatic hypotension
What is the concurrent use of NSAIDs
May decrease effect of antihypertensives
What are gastrointestinal side effects?
Acute abdominal pain, nausea
What is the absorption %?
64-90%
True or False: Amlodipine tablets can be crushed and mixed into food
True - the dose may be crushed and mixed into a small amount of soft food, such as applesauce or yogurt
What side effect occurs when used with fentanyl?
Hypotension
What are 2 cardiovascular side effects?
peripheral edema, angina, bradycardia, hypotension, palpitations
What is the peak time?
6-9 hours
True or False: During pregnancy the safety of amlodipine has been proven
False - During pregnancy the safety of amlodipine has not been proven. Amlodipine is therefore considered a pregnancy category C drug. Use amlodipine only if the potential benefit justifies the potential risk
What is safe and recommended dose of Simvastatin along with Amlodipine therapy?
Do not exceed 20mg of this drug a day
What side effect may occur in the mouth as a result of taking Amlodipine?
Gingival hyperplasia
What impacts Half-Life of this medication?
Increased in geriatric patients & hepatic impairment