Bug & Drug
Name 3 drugs that cover anaerobes
What is metronidazole, ampicillin-sulbactam, amoxicillin-clavulanate, piperacillin-tazobactam, moxifloxacin, clindamycin, cefoxitin (2nd generation cephalosporins), meropenem (carbapenems)
Recommended treatment duration for SSTIs
What is 5-7 days
Standard regimen for non-severe inpatient CAP. List class(es)
What is a beta-lactam + macrolide or monotherapy respiratory fluoroquinolone
This is the PK parameter we try to achieve when dosing cephalosporins
What is time above MIC (T>MIC) 60-70%
Positive urine cultures with pyuria require treatment with antimicrobials (True of False)
What is false
Beta-lactams that have coverage for Pseudomonas aeruginosa. Name at least 3
What is zosyn, cefepime, ceftazidime, meropenem, imipenem, aztreonam
Answer two questions. What is the recommended treatment duration for:
1. Symptomatic uncomplicated cystitis?
2. Pyelonephritis?
What is 3-5 days and 7 days
Per IDSA, this is the first line treatment for the initial episode of Cdiff
What is fidaxomicin
The AUC:MIC range that vancomycin should be dosed between
What is 400-600
These are risk factors for MRSA/Psuedomonas in CAP, name at least 2
What are recent hospitalization and parenteral antibiotics in the past 90 days, recent MRSA/Pseudomonas isolate in sputum
Name 5 agents (IV/PO) that cover MRSA
What is linezolid, vancomycin, TMP/SMX (bactrim), doxycycline, clindamycin, daptomycin, dalbavancin, ceftaroline
Also telavancin, oritavancin, tedizolid
Recommended treatment duration for uncomplicated Gram-negative bacteremia
What is 7 days
This antibiotic is the drug of choice for MSSA bacteremia (name 2)
What Nafcillin or cefazolin
These drugs are at the highest risk for causing CDiff. Name at least 3
What are clindamycin, fluoroquinolones, carbapenems, and 3rd generation (or greater) cephalosporins
Bacteriostatic abx are less effective than bactericidal abx and should be avoided in serious infections (True or false)
What is false
Fluoroquinolones and macrolides can be used for atypical organisms. Name 3 bugs
What is chlamydia pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae, Coxiella burnetii
Recommended treatment duration for uncomplicated Staph aureus bacteremia
What is 14 days (2 weeks) + ID Consult!
This antibiotic is the drug of choice for Stenotrophomonas maltophilia
What is TMP/SMX (bactrim)
List at least 3 antibiotics that do not require renal dose adjustments
Ceftriaxone, Oxacillin/Nafcillin, Metronidazole, Moxifloxacin, Azithromycin, Linezolid
List 2 antivirals (Brand and/or generic) used for HIV-PrEP
What are Truvada (Emtricitabine/TDF), Descovy (Emtricitabine/TAF), and Apretude (cabotegravir)
2 Candida spp. are often resistant to fluconazole but typically susceptible to echinocandins. Name at least one
What are Candida krusei and Candida glabrata
Recommended treatment duration for streptococcus pneumoniae meningitis
What is 10-14 days
Recommended treatment regimen for enterococcal endocarditis
What is ampicillin + ceftriaxone (preferred) or ampicillin + gentamicin
This is the mechanism behind cefepime-induced neurotoxicity
What is concentration-dependent gamma-aminobutyric acid (GABA) antagonism.
List at least 2 AmpC beta-lactamase producing organisms
What are Enterobacter cloacae, Klebsiella aerogenes (formerly Enterobacter aerogenes), and Citrobacter freundii