Name That Anemia
This anemia occurs when the body's iron stores are depleted.
Iron Deficiency Anemia
What is the normal reference range for MCV?
80–100 fL
Thalassemia affects hemoglobin production or hemoglobin structure?
Production
Which abnormal hemoglobin is produced in sickle cell anemia?
Hgb S
This macrocytic anemia results from impaired DNA synthesis and may be caused by B12 or folate deficiency.
Megaloblastic Anemia
Which iron study best represents the body's stored iron?
Ferritin
What globin chains compose Hb H?
β₄
Which amino acid replaces glutamic acid in Hb S?
Valine
This anemia occurs when iron is available but cannot be properly incorporated into heme.
Sideroblastic Anemia
In IDA, does TIBC increase or decrease?
Increase
In beta thalassemia, which two hemoglobins increase to compensate for decreased beta-chain production?
Hemoglobin F (Hb F) and Hemoglobin A₂ (Hb A₂)
What life-threatening complication of SCA presents with chest pain, fever, and respiratory symptoms with a new pulmonary infiltrate?
Acute Chest Syndrome
A patient develops a macrocytic, megaloblastic anemia due to vitamin B12 deficiency caused by a lack of intrinsic factor.
Pernicious Anemia
Both IDA and ACI can have ↓ serum iron. What iron study best distinguishes them according to our diagnostic approach?
Ferritin
An adult has 5–40% Hb H on electrophoresis. What chain is affected alpha or beta?
Alpha
A patient with SCA develops severe anemia after an infection. Their reticulocyte count is extremely LOW. Which crisis?
Aplastic crisis
A patient has anemia with a ↓ reticulocyte count. Bone marrow shows erythroid hypoplasia, while the other cell lines are unaffected. What is the congenital form of this disorder?
Diamond-Blackfan Anemia
In PNH, which two CD markers have decreased or absent expression on RBCs?
CD55 + CD59
In alpha thalassemia, what is Hb Bart’s composed of, and why is it dangerous?
γ₄ (four gamma chains); it cannot effectively deliver oxygen to tissues.
What result would you expect from a sickle solubility test if Hb S is present?
A positive test with a turbid/opaque solution, because reduced Hb S is insoluble.