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After an uneventful GA w/ isoflurane, fentanyl, and sux, a 20yo man develops diffuse muscle rigidity, tachycardia, fever of 40degC and metabolic acidemia. MH is suspected as the cause. 2.5mg/kg of dantrolene is administered every 5 min. This is the therapeutic endpoint that is the most appropriate indication to stop dantrolene administration.
What is resolution of signs that indicate hypermetabolism?
Dantrolene should be administered during episodes of MH until major cardiorespiratory effects of hypermetabolism have resolved.