Non-mammalian animals
Mammalian Animals
Presented Articles
Discussion Questions
Methods Discussed
100
Method of sleep analysis in non-mammalian animals
What is behavioral observation
100
Methods of sleep analysis in mammalian animals.
What is EEG
100
Mutations of this gene in the mouse model resulted in lack of a circadian rhythm in the double mutant mouse.
What are mPeriod genes
100
This is an advantage of using non-mammalian animals
What is simplicity of study
100
This technique was used in fruit flies to select for a specific phenotype.
What is laboratory selection
200
A characteristic of this non-mammalian model is that at an early stage in life they are transparent
What is zebrafish
200
This mammalian model has an extreme range of phenotypic variation maintained within a single species
What is canine model
200
This was the neurotransmitter affected in insomnia-like fruit flies
What is dopamine
200
This is the way you should interpret all animal model research
What is hypothesis generating study
200
This technique measures total amount of RNA in a sample
What is microarray
300
A characteristic of this non-mammalian model is it ability to reproduce quickly
What is fruit fly
300
These mice have genomic manipulations to better study the effects of specific genes on behavior
What are transgenic or “knock-out” mice
300
This is the immediate early gene that is implicated in wakefulness and brain activity
What is c-fos.
300
This has the ability to influence genetic expression
What is the environment
300
This program groups genes based upon function
What is gene ontology
400
These three pathways have been identified as being involved in sleep/wake control
What is cAMP, EGF, and cGMP
400
Canines are the first naturally occurring model for this condition related to narcolepsy
What is periodic leg movement during sleep (PLMS)
400
This was used to measure metabolic activity in mice during sleep-wake cycles
What is core temperature
400
This is the sleep characteristic that is up-regulated by mutations to Clock gene
What is NREM
400
These were the light conditions used to disrupt circadian rhythm and sleep patterns in the mouse study.
What are the entrained and free-running conditions
500
Work with fruit flies led to the discovery of this specific channel that is fundamental for regulating sleep behavior.
What is Shaker channel
500
These two things are involved in sleep regulation
What is circadian rhythm and homeostasis
500
Administration of this type of drug can be used as a treatment for PLMS in humans but cases cataplexy in dogs
What is a dopamine agonist
500
In mammalian animals, this is where the circadian rhythm is regulated
What is suprachiasmatic nucleus (SCN)
500
This technique was used to measure REM sleep by measuring eye movement
What is EOG
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