See: Mixing Red and White. Second-generation.
Chibiusa Tsukino (Sailor Moon)
A princess from the Kingdom of Clow and a girl with pink hair from Naruto
Sakura /Haruno (Tsubasa: Reservoir Chronicles / Naruto)
Double amputee at age eleven
Edward Elric (Fullmetal Alchemist)
The most well-known Yandere
Yuuno Gasai (Future Diaries)
After 25 seasons, the main character was replaced by a girl named Liko.
Pokemon
The name of Sakura Kinomoto's magical animal companion (not nickname)
Keroberos (Cardcaptor Sakura)
The prince-like rat and the "Lightning Flash" swordswoman
Asuna Yu(u)ki Sohma (Fruits Basket / Sword Art Online)
A guy who styles himself after Jason Vorhees put a centipede in his ear
Kaneki Ken (Tokyo Ghoul)
He was raised by a dragon
Natsu Dragneel (Fairy Tale)
She moves to Boston to study Law, and the rest of her friends follow after her.
Ouran High School Host Club
The length of time Homura has to keep repeating until the main character puts a stop to it.
A month (Puella Magi Madoka Magica)
He's a smoker who temporarily dates one of the villains and is called Horseface by the main character
Jean Havoc/Kirstein (Fullmetal Alchemist / Attack on Titan)
A cyborg attacked his hometown and killed everyone in it, leaving him the only survivor
Genos (One Punch Man)
She has two "Exciting" parents
Anya Forger (Spy X Family)
She ends up deciding to live the rest of her life five hundred years in the past, which I'm sure won't cause a paradox in any way.
Inuyasha
What exactly was Ichigo, the main character of Tokyo Mew Mew, fuzed with to give her powers?
Iriomote Cat
Can manipulate fire at the cost of his life and has a book of friends
Natsume Hyuuga/Takashi (Gakuen Alice / Natsume's Book of Friends)
This girl he was friends with brutally murdered his father and sister in front of him out of jealousy.
Kouta (Elfen Lied)
Some of her allies were born with powers like Tail, Tape, or even Frog! Her ability, which made not only her hair but also her skin fit this category, is called Acid.
Mina Ashido (My Hero Academia)
After changing time, he wakes up from a 18 year coma and his first order of business is to catch his mother's no-longer-murderer.
Erased (Boku Dake ga Inai Machi)
The name of Nanoha Takamachi's AI magical wand.
Raising Heart (Magical Girl Lyrical Nanoha)
The short protagonist in a sports anime who jumps high and one of the protagonists in Danganronpa
Hajime Hinata Shouyo (Haikyuu / Danganronpa)
Before this main character was born, his father sold his firstborn to demons in order to bring prosperity to his land. He is born normal and healthy, but moments later the demons take nearly every piece of him as their payment.
Hyakkimaru (Dororo)
Squad Eleven's Lieutenant
Yachiru Kusajishi (Bleach)
He travels around the entire world to steal everyone's powers, and by the time he's done he's gone slightly mad and forgotten everything about who he was and why he did it in the first place.
Charlotte