location of sympathetic division preganglionic cell bodies
What is T1-L2
100
activating an a1 receptor does what?
What is smooth mm constriction of sphincters and in circulatory system
100
Cocaine blocks reuptake of catecholamines and leaves them in the synaptic cleft to continue to stimulate receptors. What do we call this category of drug?
What is a sympathomimetic?
100
can be associated with chronic alcohol use
What is autonomic neuropathy
200
miosis
What is parasymp
200
this branch of the autonomic NS has short postganglionic fibers
What is parasymp
200
primary neurotransmitter of sympathetic NS
What is NE
200
Clonidine is a drug used to mitigate sympathetic surges that accompany opioid withdrawal. What receptor does it work on?
What is a2.
200
ptosis, miosis, anhidrosis
What is Horner syndrome
300
affects arrector pili, causing hair to stand on end
What is symp (parasymp doesn't affect skin)
300
majority of epinephrine in body is released from where?
adrenal medulla
300
you have a patient with asthma or COPD, and you want to break up their secretions - what receptor do you target?
You want to block the M3 receptor.
300
Is albuterol a beta antagonist or agonist?
What is B2 agonist.
300
super common sx of autonomic failure
What is orthostatic hypotension
400
promotes sweating
What is symp!
400
type of receptor on exocrine gland, like in the pancreas
What is parasymp (M3)
400
side effect of alpha antagonist phenoxybenzamine
What is hypotension / reflex tachy
400
NE is a great vasoconstrictor. We use it as a vasopressor in septic shock. What type of receptor does it have good affinity for?
What is alpha >> B1 >>>>>>>>>>>>>> B2.
400
pure autonomic failure is associated with ______, also found in folks with Parkinson dz
What is Synuclein accumulation
500
vasoconstriction of renal vessels
slows urine formation = symp!
500
the fibers of the greater splanchnic nerve innervate what structures?
adrenal medulla + enteric NS of the foregut
500
most common signal transduction pathway associated with autonomic NS
What is GPCRs (Gq: where PIP is cleaved into IP3 and DAG ----> Ca2+ release, etc.; Gs: activates adenylyl cyclase -> increase in cAMP--> activate PKA; Gi which is opp of Gs)
500
Isoproterenol is a pure B agonist - what sort of effects can we anticipate?
Increased CO from B1 activation and vasodilation/decreased BP from B2 activatation. Rarely used clinically.
500
SLUDGE is a toxidrome associated with what?
What is too much activation of parasympathetic NS by cholinomimetics (note: this was spelled wrong in LO - sorry!)