Rheum for improvement?
42F with bilateral hand pain and morning stiffness lasting over an hour for the past six months. Exam reveals swollen, tender MCP and PIP joints.
What are rheumatoid factor and anti-CCP?
What is anti-Centromere?
In Hashimoto thyroiditis and Graves’ disease you can see this antibody elevated in majority of cases.
What is anti-thyroid peroxidase antibody?
30F with fluctuating muscle weakness that worsens with activity and improves with rest, and difficulty swallowing. Exam shows ptosis and difficulty with sustaining an upward gaze. EMG shows decremental response to repetitive nerve stimulation.
What is acetylcholine receptor antibodies seen in Myasthenia Gravis?
Antibody present in SLE, sjogrens that increased risk of crossing placenta and causing neonatal lupus.
What is anti-Ro?
28F presents with fatigue, joint pains and a malar rash after sun exposure. She reports mouth ulcers and thinning hair.
What is anti-dsDNA, anti Smith?
c-ANCA, anti-proteinase 3
What is granulomatosis with polyangitis?
Antibody specific to Graves disease?
What is thyrotropin receptor antibody? (TRAb)
62M with 30 year smoking history presents with progressive difficulty climbing stairs, getting out of a chair and walking. Exam shows proximal muscle weakness, dry mouth. Symptoms improve after exercise. This condition is associated with small cell lung cancer.
What are autoantibodies against presynaptic voltage gated calcium channels seen in Lambert Eaton syndrome?
List of meds that can cause drug induced lupus
procainamide, hydralazine, isoniazid, quinidine, anti-TNF agent, minocycline
45M with 3 month history fatigue, arthralgia, photosensitive rash post 8 months of hydralazine therapy for HTN. Symptoms resolve within weeks of discontinuing the medication.
What is anti-histone?
45F with progressive muscle weakness and a violaceous rash over her eyelids and knuckles.
What is anti-Jo-1 seen in dermatomyositis?
32F with chronic diarrhea, weight loss and fatigue is found to have iron deficiency anemia. Duodenal biopsy shows billows atrophy.
What is anti-tissue transglutaminase (More specific) and anti-endomysial antibody seen in celiac disease?
32F with recurrent miscarriages, history of deep vein thrombosis in left leg.
What is anti-cardiolipin and lupus anticoagulant? Seen in antiphospholipid syndrome.
70M with tense, fluid filled blisters on abdomen and thighs, with recent weight loss.
Antihemidesmosome seen in bullous pemphigoid
52F with fatigue, pruritus, dry eyes with RUQ discomfort. Lab tests show increased ALP, IgM and ____
What is anti-mitochondrial antibody? AMA seen in primary biliary cholangitis
38F presents with progressive skin thickening involving her face, trunk and proximal extremities along with dysphasia and signs of pulmonary fibrosis.
What is anti-scl-70 seen in diffuse systemic sclerosis?
58F with fatigue, glossitis, macrocytic anemia with hypersegmented neutrophils and low vitamin B12 levels.
What is anti-parietal cells seen in Pernicious anemia?
In this disease, antibodies present in renal and pulmonary capillary basement membranes, with renal biopsy showing linear deposition of immunoglobulin (IgG) along the glomerular and alveolar basement membranes
What is anti-GBM antibodies against type 4 collagen?
14M with polyuria, polydipsia, and hyperglycemia
What is anti-glutamic acid decarboxylase antibody (anti-GAD) seen in type 1 diabetes?
45F with persistent dry eyes (gritty sensation) and dry mouth presents with increased thirst. Lip biopsy showing lymphocytic infiltration
What is Anti-Ro/SSA, Anti-La/SSB seen in Sjögren’s syndrome?
Antibody for mixed connective tissue disease?
What is anti-U1 RNP?
45M with asthma and allergic rhinitis history presents with worsening dyspnea, sinusitis. Labs show eosinophilia and biopsy with granulomatous inflammation with necrotizing vasculitis.
What is p-ANCA and anti-myeloperoxidase seen in Chung-Strauss/Eosinophilic granulomatosis with polyangiitis?
Antibody most specific for SLE
What is anti smith?
30F with easy bruising, petechiae, and platelet count 30
anti platelet antibodies seen in immune thrombocytopenia