structure
2 light
2 heavy
a membrane bound antibody is known as?
BCR
avidity is?
The combined strength of all interactions
igE drives what 2 major things?
allergy/parasite defense
this antibodies major function is Neutralization, opsonization, memory
IgG
Variable region form the _______ site.
antigen-binding
which regions show the greatest amino acid variation among antibodies?
hypervariable
first antibody produced?
igM
Anamnestic means?
memory
B cell receptor uses what proteins to transmit the activation signal into the B cell?
IgA and igB
what portion that determines the antibody’s class and biological function?
constant region
Hypervariable regions are also called?
complementarity-determining regions (CDRs)
which antibody is known for protecting mucosal surfaces?
IgA
A for breastmilk!!
which antibody Functions Mainly as a B-Cell Receptor?
igD
what is used for in vitro diagnostic testing?
monocolonal antibodies
name the isotypes
IgM, IgG, IgA, IgE, and IgD.
MADE G
what does antigen binding to the complmentary depend on?
shape
charge
H bonds
hydrophobic interactions
Fab Fragments Bind Without Activating which Functions?
Fc
used in antivenom
which antibody is co expressed with IgM?
igD
____ antibody is:
transfered via placenta
most abundant in blood
important in memory
igG
fab region is?
Fc region is?
Fab:two arms that bind to the antigen
binding to antigens is FAB!
Fc (fragment crystallizable):
determines class & interacts with immune cells
wht type of bond is Antigen-antibody binding?
-non covalent (reversible)
-specific
-similar to lock and key
name the basic functions of antibodies (5 in total)
NO AT
1. neutralize
2.opsonize
3. activate classical complement pathway & Mast/Esinophils
4. trigger anti-body dependent cytotoxicity
why does igM have high avidity and low affinity?
igM has more binding places but each has a lower attraction. so the sum is a high overall attraction
name the antibodies that fit in the following categories:
monomer
dimer
pentamer
monomer (2 binding sites) GED
dimer (4 binding sites) A
pentamer (10 binding sites) M