Drug Interactions
Food Interactions
Potpourri
Coumadin Dosing
100
If loaded, this antiarrhythmic drug can double the INR in as little as 24 - 48 hrs.
What is amiodarone
100
This tree like vegetable has a high vitamin k content.
What is broccoli
100
Warfarin interrupts the production of these clotting factors.
What is Factors II, VII, IX, and X. also Protein C and Protein S
100
The most common dose of warfarin.
What is 5mg daily
200
This antifungal agent has a long half life and can affect INR for days after discontinuation even if given for one dose only.
What is fluconazole.
200
Smoked or chewed this plant can decrease response to warfarin.
What is tobacco
200
Warfarin was originally marketed as this.
What is a rodentacide
200
The goal INR range for someone with a mechanical aortic valve replacement.
What is 2 to 3.
300
This drug initially causes warfarin sensitivity but with chronic treatment is an enzyme inducer
What is phenytoin
300
The smoking of this illegal plant can reduce Coumadin sensitivity
What is marijuana
300
Polymorphisms in these can affect a patient's sensitivity to warfarin.
What are CYP2C9 and VKORC1
300
This thyroid state can increase sensitivity to coumadin
What is hyperthyroidism
400
This first line agent for community acquired MRSA cellulitis can have a pronounced affect on the INR.
What is Bactrim DS or Septra DS
400
chronic alcoholism has this effect on warfarin.
What is decreases sensitivity. (acute binging can increase sensitivity)
400
Malabsorption due to diarrhea can cause a deficiency of this fat soluble vitamin.
What is vitamin K
400
Malnutrition or hypoalbuminemia has this effect on warfarin sensitivity.
What is increases sensitivity.
500
All antibiotics can theoretically increase INR via this mechanism
What is reduction of vit K producing bacteria in the gut.
500
This condiment is surprisingly high in vit k.
What is mayonnaise (or certain other vegetable oils)
500
Warfarin is an acronym for this college research group.
What is Wisconsin Alumni Research Foundation
500
Patients with this ACUTE condition can have an increased responsiveness to warfarin.
What is congestive heart failure
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