The Antidepressant Pharmacy
These are the neurotransmitters primarily targeted by bupropion.
What are dopamine and norepinephrine?
This antidepressant has the shortest halflife.
What is venlafaxine (about 5 hours)?
This antidepressant is commonly chosen during pregnancy because of its relatively favorable reproductive safety data.
What is sertraline?
The most common cortical target for TMS in the treatment of major depressive disorder is this brain region.
What is the left dorsolateral prefrontal cortex (DLPFC)?
This is the maximum FDA-approved dose of citalopram in patients over the age of 60.
What is 20mg?
The required washout period between stopping fluoxetine and starting an MAOI.
What is 5 weeks?
This antidepressant may be preferred in a patient trying to quit smoking due to its FDA-approval for this (be specific).
What is bupropion SR?
The intensity of TMS treatment is typically prescribed as a percentage of this individualized physiologic measurement.
What is the motor threshold (resting motor threshold)?
A patient with recurrent depression, severe suicidal ideation, and multiple previous depressive episodes has only partially responded to antidepressants. Which augmentation strategy has the strongest evidence for reducing suicide risk?
What is lithium augmentation?
A patient with depression is taking tamoxifen after treatment for breast cancer. Which commonly prescribed antidepressants should generally be avoided?
What are fluoxetine and paroxetine due to CYP2D6 inhibition?
This antidepressant is FDA-approved for bulimia nervosa.
What is fluoxetine?
Ketamine’s rapid antidepressant effects are thought to involve modulation of this receptor system.
What are NMDA receptors (glutamate system)?
Venlafaxine starts to inhibit norepinephrine reuptake at this dose.
What is 150mg?
(Most reuptake occurs at 225mg.)
This antibiotic can greatly increase risk of serotonin syndrome in combination with SSRIs.
What is linezolid?
What is bupropion XL?
These are the two FDA indications for esketamine (Spravato).
1. Treatment-resistant depression in adults (monotherapy or adjunct)
2. MDD with acute suicidal ideation/behavior in combination with an antidepressant
These antipsychotics are FDA approved for adjunct to antidepressants in depression.
(Name at least 4 of the 5 for correct answer).
What are aripiprazole, brexpiprazole, lumateperone, quetiapine XR, and cariprazine?
At maximum dose, bupropion IR increases seizure risk this amount from baseline.
(Must be within 2% for correct answer)
What is 0.4%?
This antidepressant was recently FDA approved for agitation associated with dementia.
What is Auvelity (dextromethorphan/bupropion)?
A patient with treatment-resistant major depressive disorder asks whether TMS or ECT is more likely to produce remission. Which treatment generally has the higher remission rate?
What is electroconvulsive therapy (ECT)?