Daring Durations
Duration of therapy for candidemia
2 weeks after clearance of blood cultures
Flucytosine dosing for cryptococcus infections
25 mg/kg 4x daily (or 100 mg/kg/day in 4 divided doses)
The broadest spectrum antifungal that causes severe nephrotoxicity
Amphotericin B
Area of the United States where blastomycosis is most common
Midwest, southeast, south-central
Duration of therapy for invasive pulmonary aspergillosis
6-12 weeks, depending on clinical improvement
Body weight used for flucytosine dosing
Ideal body weight
Antifungal causing visual hallucinations and photosensitivity
Voriconazole
Preferred oral posaconazole formulation
Delayed-release tablets
Duration of treatment for asymptomatic candiduria
0 days!
Goal trough range for voriconazole monitoring
2-5.5
Antifungal causing cardiac toxicity
Itraconazole
Antifungal agent never to be used as monotherapy
Flucytosine
Duration of consolidation therapy with fluconazole in cryptococcal meningitis
8 weeks
Itraconazole
Antifungal causing QT shortening
Isavuconazole
Biggest risk factors for mucor
Immunocompromised patients and poorly controlled diabetes
Duration of therapy for pulmonary blastomycosis infections
6-12 months, depending on clinical stability
Dose of liposomal amphotericin B for mucorales infections
5-10 mg/kg/day
Longterm use of fluconazole may cause this reversible dermatological adverse event
Alopecia
Type of cancer voriconazole use is associated with AND patient population at highest risk
Skin cancer, lung transplant patients