Drugs Basic/ Uses
ALL drugs in this class of medications are used for HIV
Protease Inhibitors
This drug works by binding to viral protein envelope, prevent virus from attaching to and uncoating to a host cell.
Fusion Inhibitors or any drug name in that class.
What metabolic side effect can occur from taking Integrase Inhibitors?
Persistent cough often makes a lot of patients unwilling to take Enfuvirtide.
What lab work besides LFTs should be monitored for Integrase inhibitors?
A1c
How should a patient avoid excessive bleeding with protease inhibitors?
The patient should use a soft toothbrush
It is the ONLY drug that prevents transmission of HIV to an unborn baby from the mother
Zivovudine (Retrovir).
Dr Lutter was asked for the shortest and easiest way to remember how this drug works, she said “Inhibit viral budding, reduce viral replication”.
Oseltamivir (Tamiflu) or Laninamivir (Inavir)
What metabolic side effect can occur from taking Integrase Inhibitors?
Persistent Hyperglycemia
Why do Reverse Transcription Inhibitors have a black box warning?
For hepatotoxicity
How should the nurse respond to a patient who asks why HIV medications are taken in combination?
The nurse should explain that HIV is commonly treated in combination due to the number of possible side effects that can occur. Medications that are dangerous should be given at the lowest therapeutic dose.
In a communal living environment, it is used to stop the spread of Flu not for treatment.
Amantadine
Nurse explained to a pt who was newly diagnosed with HIV that this drug works by breaking down peptide bond, interrupts viral replication, you know this is what class?
Protease Inhibitor.
What is the side effect of Ribavirin that has a black box warning?
Children 2 and under can develop sudden deterioration of their respiratory system if aerosolized.
True or False: The patient must have symptoms in order to receive Amantadine.
False: this medication is given to people exposed to the flu not to those that already have it.
A pregnant patient is being prescribed Zivovudine (Retrovir). She asks “Why was I prescribed this particular medication?” The nurse responds by saying….
Retrovir is specifically used to reduce transmission from mom to unborn baby.
Pt with a history of COPD and immunocompromised arrived at hospital with complaints of weakness, fatigue, muscle ache, chills, and fever. The nurse knows that these are signs/symptoms of Flu. What is the Doctor likely to prescribe for pt.
Tamiflu
True or false. Appretude blocks functions of HIV integrase, HIV virus viral needed to replicate.
True.
What is the most serious side effect that nurses should be aware of for Ganciclovir?
Blood-based adverse effects like thrombocytopenia
What should be carefully assessed with patients taking Raltavegir (Isentress)?
The skin should be carefully assessed due to the risk of Steven Johnson syndrome
What education should be given to a patient taking SYMTUZA?
SYMTUZA is a combination drug for HIV, it is generally well tolerated, but it has a black box warning due to the medication's ability to increase the risk of reactivating Hepatitis B.
"I am a BLACK BOX warning due to my severe granulocytopenia, neutropenia, thrombocytopenia and anemia. I am also wicked to pregnant mother".
Ganciclovir
Prof Toddes explained to ABSN student that this class of drug works by replaces one of the complementary bases in the chain, interrups re-zipping and prevents extension of DNA chain.
Reverse Transcription inhibitors
What common side effects apply to all antivirals?
Nausea, vomiting, and diarrhea (GI Upset)
How old does an infant have to be in order to give neuraminidase inhibitors?
At least 2 weeks old
Why should a patient be educated about frequent foot checks and avoiding hot surfaces while taking Enfuvirtide?
Enfuvirtide can cause neuropathy which increases the risk of slow healing/unnoticed wounds on the feet can cause decreased sensation to dangers like heat in the extremities.