Neoplasia basics
This must occur for cancer to arise
What is a mutation?
Classification of gene (think role in cell proliferation)
What is tumor suppressor?
APC normal effect on Beta-catenin
What is helps degrade APC?
Function of E-cadherins
What is cell-to-cell adhesion?
Through regulation of what gene does an APC mutation promote cell survival?
BCL2
Number of mutations needed for Proto-Oncogene to cause cancer
Chromosome location of APC gene
Area that Beta-catenin accumulates in without APC
What is the nucleus?
Role of Beta-catenin in cell adhesion
What is Beta-catenin helps connect E-cadherin to the actin cytoskeleton?
Major classification of BCL2
What is anti-apoptotic?
Major term for classification of epithelial malignant tumors
What is carcinoma?
Percent of patients who develop colorectal cancer that are positive for mutation in APC gene
Cell cycle checkpoint bypassed due to APC mutation
G1/S Phase checkpoint
Process that loss of cell adhesion gives rise to
What is metastasis?
Direct target of BCL2
What are BAX and BAK?
Two fundamental differences between benign vs malignant neoplasias
Inheritance pattern of APC mutation
Molecules upregulated by Beta-catenin + TCF/LEF complex
What are Cyclin D and Myc?
Two ways APC normally supports mitosis
What is (1) stabilizing microtubules and (2) associating with checkpoint proteins at kinetochores?
Mutation in another gene within Adenoma-Carcinoma Sequence that would further prevent apoptosis
More descriptive term for "adenoma" in GI tract
What is low-grade dysplasia?
Gene mutations that follow APC in classic Adenoma-Carcinoma sequence
What is KRAS and p53? (In that order)
Effect of constitutively active Wnt/Beta-catenin on RB
What is creating a Hyperphosphorylated RB?
Result of APC mutation on mitosis (specifically when classifying daughter cells)
What is aneuploidy, due to defective chromosomal segregation?
MOA for Vincristine vs Taxane