Top 200
Outside of clindamycin (Cleocin), this drug can be used for the treatment of necrotizing fasciitis via its ability to mimic the effects of clindamycin on toxin-producing bacterial species.
What is Zyvox (linezolid)?
It is often the preferrable choice as its ADE profile is more favorable and it is available via oral route. In other words, patients can go home sooner.
This drug class historically interacts with P2Y12 inhibitors by decreasing the antiplatelet effect, although there is now conflicting data.
What are PPIs/proton pump inhibitors?
These trials support the goal of 7 g/dL of hemoglobin (Hgb) as a time for transfusion target.
What are the TRICC and TRISS trials?
Overuse of this allergy product, available as both OTC and RX, may result in stunted growth/height in pediatric patients.
What is Flonase?
(**In the US, the RX strength is discontinued)
TPN (total parenteral nutrition) can largely increase a patient's risk of this kind of infection (think viral, etc).
What is fungal infection?
These drugs can lead to false readings/artifact on continuous glucose monitoring devices
What are acetaminophen (high-doses only), hydroxyurea, and vitamin C (high-doses only)?
*This is NOT an exhaustive list
This substance should never be consumed while a patient is taking Flagyl (metronidazole) OR Bactrim (sulfamethoxazole/trimethoprim) due to a disulfiram reaction.
What is alcohol?
This landmark trial for ACS (acute coronary syndromes) suggested the superiority of ticagrelor over clopidogrel for mortality and efficacy--but proved a higher bleeding risk, which is partially why the contraindication for prior TIA and others exist.
What is the PLATO trial?
This anti-arrhythmic, sometimes called 'oral lidocaine', is commonly used if a patient had at least one instance of SVT. It can be used in place of amiodarone if the patient has VENTRICULAR associated arrhythmias and the provider wishes to avoid the ADR profile of amiodarone.
What is mexiletine (Mexitil)?
Most PPIs (proton pump inhibitors) would further aggravate or cause future incidents of intrinsic AKI (acute kidney injury)--This PPI does NOT/has the LEAST risk.
What is rabeprazole/omeprazole?
This loop diuretic can be used if a patient has a sulfa allergy.
What is ethacrynic acid?
This supplement will falsely elevate T3 and T4 (thyroid hormones) and falsely lower TSH (thyroid stimulating hormone)
What is Biotin (vitamin B7)?
**This can lead to a false diagnosis of hyperthroidism or reduction of thyroid hormone dose
These trials looked at the efficacy of aspirin and clopidogrel for ACS--including NSTEMI, ischemic stroke, MI, and vascular death.
What are the CURE and CAPRIE trials?
Shortness of breath is a transient and common side effect of this oral antiplatelet drug.
What is Brillinta (Ticagrelor)?
--It is a common occurence with this agent and does NOT necessitate a therapeutic switch, but can be switched if the patient cannot tolerate the side effect.
You would use a reduced dose of prophylactic apixaban (Elliquis) if these conditions are present.
SCr >/= 1.5 AND age over 80 OR kg < 60 -->ONLY REDUCE IF BEING USED FOR PROPHYLAXIS*
Specifically for LV thrombus TREATMENT, the dose may also be reduced if the same conditions are met
ORAL amiodarone is commonly given and titrated up in divided doses due to this side effect.
*For oral formulations, GI side effects are much more common than CV side effects. However, IV formulations may cause hypotension if pushed too quickly.
This class of antibiotics can cause seizures and significantly lower valproic acid levels.
What are the carbapenems--especially meropenem?
This controversial trial suggested 5x therapy (ACEi + ARB + BB + MRA + digoxin) for patients with end-stage heart failure with reduced systolic function with LVAD implantation who were able to tolerate their effects due to mortality benefit (for this trial, defined as the patient is alive after 1 year of LVAD removal/heart transplantation).
What is the RESTAGE-HF clinical trial?
**HEAAL came before this trial, but helped develop some of the dosing protocols
This commonly occurs if Topamax is titrated too quickly OR if the dosing is interrupted for 3+ days and the patient is restarted on the same dose.
Significant decline in executive functioning and learning ability (temporarily)
*Fun fact, on APPEs, many preceptors had the fun nickname of "Stupamax" for this drug
This statin drug MUST be taken WITH food in order to be absorbed properly and produce therapeutic effect.
What is Mevacor (lovastatin)?
This SSRI is preferred in patients with CV disease and is not as likely to be associated with SIADH as other SSRIs.
What is sertraline (Zoloft)?
This interaction occurs between ciprofloxacin and tizanidine--but does not seem to be present with other fluoroquinolones.
What is increased exposure of tizanidine that may lead to hypotension and sedation effects?
*Occurs via inhibiting its cytochrome P450 1A2-mediated pre-systemic metabolism
This clinical trial, published in 2024 led to the FDA approval of acoramidis (Attruby) for the treatment of ATTR-CM (transthyretin amyloid cardiomyopathy) due to its perceived greater mortality benefit.
What is the ATTRibute trial?
**Previously, ONLY tafamidis had mortality benefit for this condition.
These anticoagulant capsules should NEVER be opened/crushed/chewed as they exponentially increase the risk of a fatal GI bleed due to vastly increased absorption/bioavailability.
What is Pradaxa (dabigatran)?
Risk of this toxicity is a primary reason Ativan (Lorazepam) is not used as a drip; ie continuous/prolonged infusion.
What is metabolic acidosis from the accumulation of toxic alcohol: propylene glycol?
**This is an additive designed to increase the solubility of injectable formulations of lorazepam