This puzzle game's name is a shortening of a Japanese phrase that means "the numbers are restricted to single status"
Sudoku
You'll spend a lot of time on I-95 going from Maine to Georgia, maybe to see a major golf tournament. (Starts with A)
Augusta
The long, narrow part of a guitar that carries the strings from the body to the headstock has this anatomical name
A neck
Spring begins officially at this cosmic moment of equal parts day & night
The equinox
To offer something for purchase, or the basic structural unit of an organism
Sell/cell
Stay out of my affairs: MYOB
Mind Your Own Business
Species of this cephalopod with 10 appendages include the colossal, which can be 40' long, & the southern pygmy, less than 3/4"
Squid
While recovering from polio in 1948, teacher Eleanor Abbott invented this "sweet" board game for the children in the ward to play
Candy Land
Interstate stops in Cleveland & Cheyenne may await on a trek from Maine's largest city to Oregon's
Portland
Don't worry, we're sure you know this word for the strips of metal embedded in a guitar's fingerboard
Frets
MLB fans are full of boundless optimism during this, another term for baseball's preseason
Spring Training
A measure of gold purity, or a Bugs Bunny favorite
Carat/carrot
Hold on now:
JAS
Just A Second
One look at the forehead of the genus Naso, & you'll see why it's also known as this fish.
Unicorn Fish
Richard Garfield "Gather"ed his wits to create this 1993 fantasy card game
Magic: The Gathering
Interstate stops in Cleveland & Cheyenne may await on a trek from Essex County, Mass. to Marion County, Oregon
Salem
A guitar's strings are set to E-A-D-G-B-E in "standard" this
Tuning
A state flower, the California species of this blooms in great numbers in the spring.
A Poppy
A female antelope, or material to be baked
Doe/dough
Occurring away from the Internet:
IRL
In Real Life
The polyp is the body of this creature whose name also refers to its skeleton; masses of them form reefs
Coral
Created in 1959, these dolls named for a creature of Scandinavian folklore were known for their unique hairstyles
Trolls
You'll head south on I-65--& remember I said south--when you go from Miami University to the University of Mississippi
Oxford
Guitarists use picks, also known by this other "P" word
Plectrum
Observed in spring, Beltane Eve is a major celebration for these modern-day followers of witchcraft
Wiccans
To fire a nerf blaster, or a sloping channel for water
A bit similar to IMHO:
FWIW
For What It's Worth
A major type of these free-floating ocean organisms, with a name from Greek for wandering, dinoflagellates can cause red tides.
Plankton
George Lerner originally had trouble selling this toy because after WWII it seemed wasteful to make toys using veggies
Mr. Potato Head
You start on Interstate 91 out of the one in Massachusetts & you end up on I-55 to reach the one in Illinois
Springfield
This type of clamp raises the pitch of a guitar's strings.
Capo
The modern tradition of spring break began in the 1930s as part of a swim meet in this Florida city named for a military man
Fort Lauderdale
A lowly servant in the era of knights, or the central part of a church
a knave/nave
I only skimmed it: TL;DR
Too Long; Didn't Read
A brown alga, this largest seaweed can grow 200 feet long & forms forests off the California coast
(Giant) Kelp