Metabolic syndrome
BMI formula
BMI = kg/m2
BMI cutoff for underweight
Name a pharmacological weight loss agent
1. Liraglutide (GLP1 agonist)
2. phenteramine (sympathomimetic appetite suppressants)
3. Orlistat (lipase inhibitor)
4. Naltrexone-bupropion (mixed mechanism)
Name two statins
rosuvastatin, atorvastatin, simvastatin, pravastatin, lovastatin, fluvastatin
10 things I hate about you: "I know that you can be overwhelmed and you can be underwhelmed, but can you just we whelmed?"
"I think you can in Europe."
Criteria for metabolic syndrome
3+ of the following: insulin resistance, elevated BP, elevated triglycerides, low HDL, abdominal obesity
BMI cutoff for obesity
>30
MOA of Ezetimibe
Inhibits absorption of cholesterol at intestinal brush border
MOA of statins
Inhibition of HMG-CoA reductase, inhibiting hepatic cholesterol synthesis and leading to upregulation of LDL receptors on hepatocytes
Notting Hill iconic line
"I'm just a girl, standing in front of a boy, asking him to love her."
treatment for metabolic syndrome
aggressive lifestyle modification (diet, exercise, weight loss, smoking cessation)
Name a medical condition causing 2' obesity
What is the most effective agent to increase HDL?
Niacin (aka vitamin B3)
Name one indication for statin use
1) known atherosclerotic CV disease (CAD, stroke, PAD)
2) LDL>190 mg/dl
3) Diabetes age 40-75years
4) Estimated 10-year ASCVD >7.5% ** (guidelines vary)
Should Jack Black have ended up with Kate Winslet in "The Holiday"?
No.
Cutoff for HgA1C
5.7-6.4% = prediabetes
6.5+% = diabetes
Name the stages of behavioral change
precontemplation, contemplation, preparation, action, maintenance, (relapse)
Name a drug that can cause dyslipidemia
Thiazide, beta blockers, OCP, protease inhibitors
Name 2 adverse effects of statin use
1) Myalgias
2) Hepatic dysfunction
3) GI upset
Who stars as Joe Fox's (Tom Hanks) friend in "You've Got Mail"?
Dave Chappelle
Indications for bariatric surgery
BMI>40 or BMI>35 with weight-related comorbidity who have not succeeded weight loss with other treatments
Name the 5 A's of Behavioral Counseling
1. Assess
2. Advise
3. Agree
4. Assist
5. Arrange
PCSK9 inhibitors belong to which drug class (eg, small molecule, mAb)
PCSK9 inhibitors are mAbs administered subQ at 2-4 week intervals
Can you use a statin in pregnancy?
No, but statins are safe to prescribe in patients who are not pregnant but may become pregnant. Reassure patients who have an unintended exposure to statins in early pregnancy that it is unlikely to cause harm to the developing fetus.
Who wrote the soundtrack for Call Me by Your Name
Sufjan Stevens