Indication
60 years and older
and
18 through 59 years of age who are at increased risk for RSV-LVTD.
What is Arexvy indicated for?
Patient empathy
Vaccine Fatigue
Lack of knowledge on coverage/insurance
What is the competition for SHINGRIX?
3-6 days
10-31% in ICU
6-8% mortality
What are the severe consequences for the older adult patient getting hospitalized with RSV?
99.5% of adults ≥ 50 years of age in the US have had chickenpox, even if they don’t remember it
What is the % of people infected with the varicella zoster virus (VZV)?
ASTHMA
COPD
DIABETES
CAD/CHF
What are the comorbidities that RSV can impact and lead to serious complications?
vaccine indicated for prevention of herpes zoster (shingles) in adults aged 50 years and older.
SHINGRIX is not indicated for prevention of primary varicella infection (chickenpox).
What is SHINGRIX indicated for?
There is no head to head trial against the competition.
What is your response to questions regarding the competition?
Mild, cold like symptoms, but can progress into severe lower respiratory tract infections, like pneumonia.
How does RSV present?
1 in 3
How many people will develop shingles in their lifetime?
Patients aged 50 years and older with CAD experienced higher incidence rates of RSV-associated hospitalization compared with those without CAD,
at a higher incidence rate of 3.7 - 6.5
Is there a higher incidence of hospital in patients with comorbidity of CAD?
Adults 50-74 years of age who are at increased risk of severe RSV illness receive a signal does of RSV vaccine.
Adults 75 years of age and older receive a single dose of RSV vaccines.
What is the CDC recommendation for RSV vaccines?
apathy
vaccine fatigue
What are the competitors for SHINGRIX?
There are an estimated 14,000 RSV deaths and 16,000 to 43,000 influenza deaths annually of adults aged 65 years or older.
How does RSV compare to influence on the impact of adults aged 65 years and older?
POSTHERPETIC NEURALGIA
OCULAR
CUTANEOUS
NEUROLOGICAL
STROKE
What are potential complications of shingles can be serious?
24%
What is the INCREASED RISK OF SHINGLES
in patients with DIABETES vs without?
for the prevention of HZ in immunocompetent adults ≥50 years and older, regardless of whether a patient reports a prior dose of Zostavax
What is SHINGRIX recommendation by the CDC?
Arexvy effectivesness 83% and Abrysvo effectiveness 73%
There are an estimated 14,000 RSV deaths and 16,000 to 43,000 influenza deaths annually of adults aged 65 years or older
How does RSV compare to Flu in regards to deaths?
diabetes
chronic kidney disease (CKD)
cardiovascular conditions
Psychological stress
What are the risk factors that have been associated with an increased risk of shingles?
Approximately 38% of patients aged 60 years and older with CHF experienced exacerbation during hospitalization with RSV in one study
What is the potential of exacerbation during hospitalization with RSV for adults aged 60 years and older with CHF?
Chronic lung or respiratory disease
Chronic Cardiovascular disease
Chronis liver disease
What are three CDC-identified Risk Factor for RSV vaccination?
Arexvy was associated with estimated 71.4% lower risk of hospitalization among patient with COPD
Arexvy was associated with estimated 773.1% lower risk of hospitalization among patient with Asthma
What were the results from the Clear VE RSV Vaccine effectiveness study?
–Average length of stay of 3-6 days
–10% to 31% were admitted to the ICU
–Average mortality rate of 6% to 8%”
What is the consequences of a patient with RSV being admitted to the hospital?
approximately 9 out of 10 patients
What many SHINGRIX patients experienced significant pain?
SHARPLY INCREASES STARTING AT AGE 50.2
These patients may have additional risk factors including
CERTAIN CHRONIC CONDITIONS and PSYCHOLOGICAL STRESS
What are the risk factors associated with SHINGRIX?