Name Disorder
Three distinct characteristics of RA
Inflammation, autoimmune, degeneration
stiffness of muscles and pain in the neck, shoulder, and pelvic. Form of vasculitis
Giant Cell arteritis (GCA)
Filgrastim (used for neutropenia) Colony stimulating factor
Neupogen
used to treat cancer, RA, immunosuppressant. Used in combination with NSAIDS
Methotrexate (MTX) DMARDS
Teach patients to report signs of infection immediately: Sore throat, Diarrhea, Vomiting Fever of 100.5° F (38.1° C) or higher
what is all immunosuppressant meds?
Butterfly rash, discoid cutaneous lesions exacerbated by UV light, photosensitivity
SLE (systemic lupus erythematosus)
One of the most common autoimmune disorders, affecting approximately 1 out of 1000 people or 2 to 4 million people in the US. Involves lacrimal and salivary glands
what is Sjogren's
Manufactured in kidneys, makes red blood cells
erythropoietin
caution if High BP, HgB greater than 10
can increase blood volume and cause clotsif too much red blood
Screen for TB prior to giving, monitor for TB during treatment. Used to treat RA
Humira (adalimumab) DMARD
Take first thing in the morning. Take it at least 30 minutes before any foods, beverages (except plain water), or other drugs. Do not crush
What are Bisphosphates Fosamax (alendronate)
Used to tx Osteoporosis full glass of H2O, erodes esopahagus
exacerbation and remission
what are rheumatic diseases
RA treatment
Manage pain, rest, community resources, depression Application of heat or cold Massage, position changes, rest, Foam mattress, supportive pillow, splints.
ADE muscle relaxants
drowsiness, euphoria, lightheadedness, fatigue, muscle weakness
Restore the immune system’s function if it is impaired. Augment the immune system’s ability to function as the body’s defense.
Interferons used to Rx Hepatitis C, MS
Orencia
Used to treat RA
Caution if the patient has a history of recurrent infections or chronic obstructive pulmonary disease
Patients must be up to date on immunizations before starting therapy
May increase risk of infections associated with live vaccines
May decrease response to vaccines
Dry gritty Eyes, xerostomia
Sjogren's
face appears masklike, immobile, and expressionless, and the mouth becomes rigid
Scleroderma
available in injectable form (pump) for spasms
what is Baclofen (lioresal)
Hematopoetic drugs
promote the synthesis of various
types of major blood components
by promoting the growth, or
differentiation, and function of
their precursor cells in the bone
marrow. (after chemo etc)
what are MAB's?
Treatment of cancer, rheumatoid arthritis (RA), MS, and organ transplantation
Specifically target cancer cells and have minimal effect on healthy cells
monoclonal antibodies
diagnose RA
Sed rate (ESR) Rheumatoid factor, ANA, CRP, XRAY, H and P, physical exam
mouth will have dry and sticky mucous membranes. reduced saliva production may lead to difficulty swallowing.
Sjogren's
when to give hypnotics
what is 30-60 minutes before bed
Treat Malaria, RA and SLE? COVID
What is Hydroxychloroquine (Plaquenil)?
Monitor eyesight, baseline EKG can cause Prolonged QT syndrome
These muscles relaxants cause REM rebound and a tired feeling the next day; use with caution in older adults. Reversal agent is Flumazenil
Benzodiazepines, end in "pam"
alprazolam, diazepam
Starts insidiously with Raynaud’s phenomenon and swelling in the hands.
what is Scleroderma
•Wrinkles and lines are obliterated. Skin is dry because sweat secretion over the involved region is suppressed.
Scleroderma
muscle relaxants
similar to CNS depressants (sedation), resemble GABA, work on skeletal muscle
must be screened for latex allergy (some dosage forms may contain latex)
What is Embrel (Etanercept) DMARD?
ØContraindicated in presence of active infections
•Reactivation of hepatitis and tuberculosis have been reported.
this muscle relaxant produces little sedation
Flexeril (Cyclobenzaprine)
cutaneous manifestations include splinter hemorrhages, alopecia, and Raynaud’s phenomenon.
SLE
Also called temporal arteritis because the majority of arteries affected are extracranial branches of the carotid artery.
GCA (giant cell arteritis)
antidote for Benzodiazepines
what is Flumazenil?
Caution if history of recurrent infections or COPD must be up to date on immunizations before starting therapy. Used for RA
What is Orencia (Abatacept) DMARD
Muscle relaxant used to treat MS, Parkinson's and is the drug of choice to treat Malignant Hyperthermia a)(serious ADE of certain types of paralytic anesthetics) used in OR
what is Dantrolene (Dantrium)