General Immunology Facts
The name of the cell that is responsible for phagocytosis and antigen expression
Macrophage/monocyte
The immunoglobulin responsible for immediate hypersensitivity allergic reactions
IgE
Small compounds that have to be linked to a larger molecule to react with an appropriate antibody
Hapten
The complement component where all pathways converge
C3
The cells that are often increased in parasitic infections
Eosinophils
The type of immunity that is immediate and is non-specific and has no memory
Innate
The first immunoglobulin produced in a primary immune response
IgM
The binding of an antibody to an antigen other than the one that induced its formation
Cross-reaction
What components make up the MAC attack complex?
C5-C9
A cell that is the result of a B cell becoming activated
Plasma cell
The group of diseases that occur because there is a failure in the self-recognition part of the immune system
Autoimmune diseases
The Secretory Immunoglobulin
IgA
The site on the surface of an antigen molecule to which an antibody attaches itself
Epitope
Deficiencies of C1-C4 tend to be linked to what group of diseases?
Autoimmune disease
The lymphocytes that are the first line of defense against cancer cells and virus-infected cells
Natural Killer T cells
Explain the difference between an antigen and an immunogen.
An immunogen is any substance capable of inducing an immune response;An antigen is the target of the immune response, but it doesn't necessarily induce an immune response.
The two forms that immunoglobulins can occur in
1. Soluble 2. Membrane-bound
Substances that enhance the immune response against an immunogen
Adjuvant
Type I hereditary angioedema is usually caused by a gene mutation which causes a decrease in the production of what substance?
C1 inhibitor
Cells that are produced in the bone marrow and mature in the thymus
T cells
What are the four "R"s that define the functions of the immune system?
1. Recognize
2. Repel
3. Regulate
4. Remember
The IgG subclass that is best at fixing complement
IgG3
What is the difference between affinity and avidity?
The initial strength of response of ag/ab is affinity.
A measure of the overall binding strength of the antigen/antibody reaction is avidity.
List the C3 convertase for both the alternative and classical pathway
Classical: C4bC2a
Alternative: C3bBb
What are the 3 types of T cells?
T helper, T suppressor, NK (cytotoxic)