Pathophysiology
What are the 3 primary receptors?
Alpha 1
Beta 1
Beta 2
Examples of this medications include but not limited to
Atenolol
metoprolol
bisoprolol
Any medication that ends in "lol"
Beta-Blockers
Stimulates a sympathetic response due to being a sugar bypassing beta receptors and calcium receptors increasing heart rate and contractibility.
Glucagon
Symptoms including bradycardia, hypotension, seizures and ekg changes such as QRS widening and QT prolongation.
Beta blocker overdose
Initial Glucagon dosage for beta blocker/ calcium channel blocker overdose?
Located predominantly in the lungs
Relaxes and dilates
Beta 2
Example of this medication include but not limited to
Amlodipine
Dilitiazem
Verapamil
Calcium Channel blocker
A class of medication that bind to the channels blocking calcium from entering the cels, causing vasodilation, that then cause a decrease in blood pressure.
Calcium channel Blockers
Can cause hyperglycemia, sinus arrest, 1st-3rd degree AV block.
Calcium channel blocker overdose
Calcium chloride dosage for Beta blocker/calcium channel blocker overdose
Located predominantly in the arteries
Vasconstriction
increase in Blood pressure
Alpha 1
First line drug based off of PCEMS protocol TE 7 to treat Beta blocker or calcium channel blocker overdose.
Glucagon
Is movement of substances into or out of a cell requiring the expenditure of engird in the form of ATP
Active transport
SLUDGE acronym stands for?
Lacrimation
Urination
Deficartion
GI distress
Emesis
Narcan dosage if respiratory compromise is taking place
0.4-2mg
Located predominantly in the heart
Increase in blood pressure
Beta 1
Second line drug based off of PCEMS protocol TE 7 for a beta blocker or calcium channel blocker overdose.
Calcium Chloride
This provides energy for physiological processes such as muscular contraction.
ATP or adenosine triphosphate.
DUMBBELS stands for?
Diarrhea
Urination
Miosis
Bradycardia
Bronchorrhea
Emesis
Lacrimation
Salivation
Pediatric Glucagon dosage in a beta blocker/calcium channel blocker overdose
0.1mg/kg
Adrenergic receptors
Drug given in any overdose based on PCEMS protocol with inadequate respirations/oxygenation/ventilation.
Narcan/ Naloxone
A substance that interferes with or inhibits the physiological action of another.
Antagonist
This type of drug causes Increased HR, Increased temperature, dilated pupils and mental status changes.
Anticholinergic
Pediatric dosage for calcium chloride in beta blocker/ calcium channel blocker overdose
20mg/kg
Name the 2 drugs that PCEMS carries that are AGONIST, which are a substance which initiates a physiological response when combined with a receptor. They have all 3 effects, Alpha 1, Beta 1 and Beta 2.
Epinephrine/norepinephrine.