Hemoglobin
This structural relative of hemoglobin is found in muscle tissue and has a higher affinity for oxygen.
What is myoglobin?
What molecule is
recognized by and gets
bound to by antibodies?
What are antigens?
A nucleophilic substitution
reaction that involves the
formation of a tetrahedral
intermediate.
What is SN1?
This equation describes a
change in free energy given
an equilibrium constant.
What is -RTlnKeq ?
There are two different modes of enzymatic catalysis: chemistry and this.
What is: binding?
This form of myoglobin has iron in the Fe³⁺ state and is responsible for the brown color in aged meat.
What is metmyoglobin?
This class of immunoglobulins is found in mucous membranes and provides the first line of defense against pathogens.
What is IgA?
A nucleophilic substitution
reaction that involves direct
displacement of groups and
has a transition state.
What is SN2?
This equation describes the velocity of an enzymatic
reaction when two of the three factors are known.
Maximum velocity, substrate concentration, Michaelis-Menten constant.
What is V0=Vmax[S]/Km
According to Dr. Schineller, this mode of catalysis is involved in binding and is "almost always present" in mechanisms.
What is: proximity and orientation?
The oxygen-binding curve of hemoglobin has this distinctive S-shaped appearance.
What is a sigmoidal curve?
The heavy and light chains of immunoglobulins are connected by this type of chemical bond.
What are disulfide bonds?
The Triose Phosphate
Isomerase Reaction
proceeds by this
mechanism.
What is general acid-base
catalysis?
This equation describes the linear transformation of the Michaelis-Menten plot.
What is 1/V0 = (Km/Vmax)(1/[S]) + (1/Vmax) or
Lineweaver-Burke equation?
This mode of catalysis accelerates a reaction by catalytic transfer of a proton, and net change is ultimately conserved.
What is: acid-base catalysis?
This condition is characterized by abnormal hemoglobin molecules and is the most common inherited blood disorder.
What is sickle cell anemia?
This region of an antibody is responsible for binding to specific antigens.
What is the Fab (Fragment antigen-binding) region?
This reaction involves the transfer of a gamma-
phosphoryl group from an ATP molecule to the oxygen
at the C-6 of glucose.
What is the hexokinase
mechanism?
This equation describes the equilibrium constant of a
reaction.
What is Keq = [products]/[reactants]
Enzymes may bind 10^10 to 10^15 times more tightly to their transition states rather than their substrates in this mode of catalysis?
What is: transition-state stabilization?
This amino acid residue in myoglobin is crucial for stabilizing bound oxygen and is often called the "distal _____".
What is histidine?
This region of an antibody interacts with effector cells and complement proteins.
What is the Fc (Fragment crystallizable) region?
This reaction occurs to form Schiff base.
What is Aldol condensation?
This equation describes the velocity of a second-order
rate reaction.
v=k[S1]^1[S2]^1
This mode of catalysis, also, called electrostatic catalysis, acts in binding and orientation of substrates and includes redox reactions.
What is: metal-ion catalysis?