Viruses
Very small (30-300nm), obligate Intracellular parasites, very specific, composed of protein shell (capsid), Contain DNA OR RNA (not both), DNA (ss or ds), RNA (ss+ or -, or ds), may have lipid envelope or enzyme associated, are NOT CELLS!
What are the characteristics of Viruses?
Cancer of connective tissues
What is Sarcoma
particles that contain no genetic material and are inherited and transmitted by ingestion, transplant, and surgical instruments
What are Proteinaceous infectious particles?
the ability to cause disease
What is Pathogenicity?
Microorganisms that colonize human body and don't cause disease in normal conditions
What is Normal Flora (microbiota)?
Bacterial, Plant, or Animal/Human
What are 3 types of viruses?
Caused by oncogenic viruses or carrying oncogenes
What is Cancer
Causes Mad cow disease and cheep scrapie
Spongiform encephalopathies
The degree (measurement) of Pathogenicity
What is Virulence?
______ Colonizers such as E. Coli, Streptococcus, Clostridium
What are Early colonizers?
Attachment to cell membrane, Entry by endocytosis or fusion, Uncoating by enzymes, Biosynthesis production of nucleic acid and proteins, Maturation nucleic acid and capsid proteins assemble, Release by budding (enveloped) or rupture
What is the process of Animal Virus multiplication?
Cancer of glandular epithelial tisue
What is Adenocarcinomas?
located on cell surface and known to be a normal cellular prion protein
What is PrPC
The colonization of the body by microorganisms
What is an infection?
Eyes, Nose and throat, mouth, large intestine, and the urogenital system
What sites of the body are heavily colonized?
A series of changes or abnormalities in virus-infected cells including:
Giant cell formation, vacuolation, chromosome breakage, or cancer
What are cytopathic effects of viruses?
Virus that is asymptomatic in host cell for long periods (reacts to changes in immunity)
Latent Virus
A type of protein that accumulates in the brain cells forming plaques
What is PrPSc?
multiplication of pathogen after it accesses host tissues
What is colonization?
Beneficial aspects of this flora keeps out invaders, produces useful substances, and provides immune stimulation
What are beneficial aspects of normal flora?
Papovaviridae
What is the name of a double stranded DNA enveloped Papillomavirus?
Occurs gradually over a long period and is generally fatal
What is a persistent viral infection?
Causes CJD (Creutzfeldt-Jakob disease)
Spongiform encephalopathies
injury to the host that impairs host function
What is Disease?
_________ sites of the body such as:
blood, cerebrospinal fluid, and synovial fluid
What are sterile sites of the body?