General
SSRIs
MAO Inhibitors
TCAs
BONUS 500
100
Antidepressants work by _________ the amount of certain ________ in the brain.
Increasing, neurotransmitters
100
What does SSRI stand for?
Selective Serotonin Reuptake Inhibitors
100
What does MAO stand for?
Monoamine oxidase
100
What does TCA stand for?
tricyclic antidepressants
200
What is a neurotransmitter?
Chemicals that transmit signals across a synapse from one neuron to another 'target' neuron.
200
Why are SSRIs considered selective?
Because they primarily affect serotonin.
200
What is an MAO?
A natural enzyme that breaks down neurotransmitters.
200
CONGRATULATIONS
This is a bonus! You have just collected 200 free points and a piece of candy!!
300
Name at least four conditions that antidepressants are used for.
depression, generalized anxiety disorder, agitation, obsessive compulsive disorders (OCD), manic-depressive disorders, childhood enuresis (bedwetting), major depressive disorder, diabetic peripheral neuropathic pain, neuropathic pain, social anxiety disorder, posttraumatic stress disorder (PTSD)
300
What is serotonin responsible for?
Maintaining mood balance
300
How do TCAs work?
They block the reuptake of serotonin and norepinephrine, allowing more of the neurotransmitter to be available in the brain.
400
What is a neuron?
A specialized cell responsible for transmitting nerve impulses.
400
How do SSRIs work?
They block the reuptake of serotonin in the brain. This changes the balance of serotonin which helps brain cells send and receive messages. The sending and receiving of these messages boosts mood.
400
How do MAOIs work?
They disrupt the MAOs from destroying the neurotransmitters in the synapse. The increased amount of neurotransmitters allows more messengers available to receive the neuron, reducing the chance of depression.
400
What is the difference between a tricylic and tetracylic antidepressant?
The number of rings in their chemical structure — three (tri) or four (tetra)
500
Low levels of _________ and _________ in the synapse are associated with sadness and depression.
Serotonin, Norepinephrine
500
Name 3 generic names or brand names for SSRIs used to treat depression
-Citalopram (Celexa) -Escitalopram (Lexapro) -Fluoxetine (Prozac) -Paroxetine (Paxil, Pexeva) -Sertraline (Zoloft)
500
Name 2 commonly prescribed MAOIs.
Marplan (isocarboxazid) Nardil (phenelzine) Emsam (selegiline) Parnate (tranylcypromine)
500
Name 3 tricyclic antidepressants.
Amitriptyline Amoxapine Desipramine (Norpramin) Doxepin Imipramine (Tofranil) Nortriptyline (Pamelor) Protriptyline (Vivactil) Trimipramine (Surmontil)
500
Explain the movement of a neurotransmitter from a sending neuron to a receiving neuron.
The neurotransmitters leave the sending neuron and enter the space between the sending and receiving neurons. This space is called the synapse. The neurotransmitters then hook up to a receptor on the receiving neuron to deliver their message. Once neurotransmitters have sent their message, they return and can be reabsorbed by the sending neuron in a process called reuptake. Reuptake allows the messengers to be reused.
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