Diagnostic Clues
SSRI Clues
Differential Dx
Escalation Thresholds
200

This symptom is more predictive of bipolar disorder than elevated mood.

What is decreased need for sleep?

200

Insomnia, irritability, and increased productivity shortly after starting an SSRI may represent this.

What is antidepressant activation?

200

This condition, which causes impulsivity, is chronic and lifelong rather than episodic.

What is ADHD?

200

Three nights of 3 hours sleep with rising productivity requires this action.

What is urgent review?

400

This is the most heritable mood disorder.

What is bipolar disorder?

400

This medication class, when used alone in bipolar disorder, may increase risk of mood destabilization.

What are antidepressants?

400

Mood shifts occurring over hours and triggered by relationships are more consistent with this diagnosis.

What is borderline personality disorder?

400

Mixed features plus suicidal ideation requires escalation within this time frame.

What is same-day?

600

In relapse prevention, this is usually the first biologic sign of mania.

What is reduced sleep?

600

If a patient becomes more agitated and sleeps less after starting sertraline, this should be concerning for ____.

What is antidepressant-induced mania?

600

The key feature that distinguishes bipolar II from BPD is this biologic change.

What is decreased need for sleep?

600

Stopping a mood stabilizer abruptly should trigger this.

What is urgent review?

800

If sleep drops below this number of hours for several nights with rising energy, escalation should be considered.

What is fewer than 4–5 hours?

800

Worsening cycling after SSRI addition may indicate this underlying vulnerability.

What is bipolar spectrum disorder?

800

People with this disorder have mood reactivity that's chronic and have identifiable triggers. 

What is trauma-related disorder or personality disorder?

800

Mild insomnia without activation may be appropriate for this approach.

What is close monitoring?

M
e
n
u