DSM
What are the two core symptoms of a manic episode (Criterion A)?
(1) elevated/expansive/irritable mood + (2) increased activity/energy
Which second generation antipsychotics are most effective for stabilizing acute mania?
Zyprexa and risperidone
What is the target blood level for lithium and depakote in bipolar disorder
Depakote 50 to 125 mcg/mL
Lithium 0.8 to 1.2 mEq/L (acute mania)
Hypnagogic
(of a hallucination) while going to sleep
Star Wars' Princess Leia actress
Carrie Fisher
In order to qualify as a hypomanic episode, the period of elevated/expansive/irritable mood must last how long?
4 days
This "SGA" finished second in NBA MVP voting for the 2023-24 Season
Shai Gilgeous Alexander (Oklahoma City Thunder)
Lithium's utility as a mood stabilizing agent was discovered by John Cade, a psychiatrist from which country?
Australia
Erotomanic
(of delusions) that someone (usually unattainable) is in love with the patient
Pop singer known for hits like "Hot to Go" and "Red Wine Supernova"
Chappell Roan
Bipolar I diagnosis requires a manic episode. What is the episode requirement for a Bipolar II diagnosis?
hypomanic episode + depressed episode
Name the 5 FDA approved medications for Bipolar Depression
quetiapine, lurasidone, lumateperone, cariprazine, and olanzapine/fluoxetine combination
"Lithium" was a hit from this band's 1991 album, Nevermind
Nirvana
Clang
Grouping of words/speech based on sound (e.g. rhyme) rather than logical relation
Dutch painter who severed his own ear
Vincent van Gogh
If the mood is "irritable" how does this effect the diagnostic requirements of a manic episode?
From Criteria B symptoms, 4 symptoms required instead of 3 (DIGFAST/GSTFDAR)
What was the first SGA to be brought to market in the US?
Clozaril (1990)
Describe the kindling hypothesis in relation to bipolar disorder
Kindling (borrowing from evidence on seizure activity) suggests that recurrent mood episodes (both manic and depressive) progressively lower the threshold for subsequent episodes, making them more frequent, more severe, and easier to trigger over time.
repeated purposeless movement/activity
Film director behind The Godfather, Apocalypse Now, and Megalopolis
Francis Ford Coppola
Describe the criteria for Schizoaffective Disorder Bipolar Type
Schizoaffective:
1) Criterion A of schizophrenia is met;
2) major mood episode criteria are met for a MAJORITY of the total illness time;
3)Delusions or Hallucinations must be present for 2 weeks WITHOUT mood episode during the lifetime course of an illness
Which receptor targets of SGAs are implicated in weight gain?
Histamine 1 antagonism
5HT2c antagonism
Muscarinic 1 antagonism
Lamictal is infamous for the risk of SJS/TEN. What are the criteria for SJS and TEN?
SJS involves less than 10% of skin surface. TEN greater than 30%. Mortality rate for TEN is 30-40%
Verbigeration
Repetition of phrases "like a scratched record"
The "genius" lead songwriter for the Beach Boys
Brian Wilson