This is the only systemic retinoid used to treat psoriasis.
Acitretin.
Common triggers of LP. Name one for each:
Microbe
Drug
Contact allergen
Microbe – HCV
Drug - HCTZ
Contact allergen – Mercury amalgam
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answer
Common mutation in atypical melanocytic nevus
CDKN2A
Common mutations in
1. chronic sun damaged skin, nodular melanomas,
2. non-CSD skin, superficial spreading melanomas
In psoriasis, keratinocytes secrete these antimicrobial proteins.
hBD-1,2, Cathelicidin LL37, SLPI
hBD = human β-defensin 1-2
SLPI = Secretory Leukocyte Protease Inhibitor
This form of LP can develop into follicular-based SCCs
Which of the two, Dsg1 or 3 antibodies cross placenta?
Dsg3. Transient blistering in infant
Is DPN part of blue nevus family?
Factors in tumor classification within the TNM system
This inherited autoinflammatory disorder can fool us into thinking it is generalized pustular psoriasis.
DIRA (deficiency of IL-1 receptor antagonist),
DITRA (IL-36 RA), ADAM-17 deletion, CARD-14 mediated pustular psoriasis.
I am LP Pemphigoides. Sing my praise, tell my story. Who am I? How do I come to be?
IgG against BPAG2 (180 kD of Col XVII); post LP; uninvolved skin
I am Dsg1. Since you are now experts in blistering conditions, I challenge you to name one other condition that I am involved in.
Dsg1 cleaved in SSSS
Nevus of Ota can lead to this in 10% of patients
Glaucoma
You are in Dr.Chu’s lecture, you see shades of pink and blue on your screen. With some magic synapses in your brain, you narrow it to subepidermal bullous disease. He zooms in on the blister. There are ants in the blister and on tips of papillary dermis….he is quite, waiting for your answer. And your answer is?
He asks: “Are you sure? Do you want to sign this as a diagnosis?” Then you remember this session, and you say the right answer. And that is?
LABD
No, need DIF to differentiate from DH
A type of PRP that has sclerodermoid changes of hands/feet.
Type 5.
This syndrome has four names and three significant clinical findings. Classified as a variant of LPP (lichen plano pilaris)
Graham-Little-Piccardi-Lasseur syndrome;
Biopsy for DIF should be lesional from the center of a bulla.
Result 1: You are a star! You are praised by Dr. Mitre for your acute attention. or
Result 2: You are a learner and strong! You prepare to face the consequences as biopsy comes back non diagnostic because they cannot find the epidermis.
Result 2
You are a learner and strong! You prepare to face the consequences as biopsy comes back non diagnostic because they cannot find the epidermis.
Activating mutations in these are seen in 83% of patients with blue nevus
Parade of antigens!! Next up, LABD
1. This question is a good practice to ask patients coming in with guttate psoriasis.
2. Do this at your own risk of developing erythrodermic psoriasis.
1. Have you had any sore throat and related symptoms in the recent past 3-4 weeks prior? i.e. URI (Strep throat)
2. Abrupt withdrawal of steroids (taper, taper, taper)
1. Most patients with LS have circulating antibodies against
2. Protein in the prev question is mutated in this condition
1. ECM-1 (Extra Cellular Matrix protein)
2. Lipoid proteinosis
What is IIF? What substrate is used for PV? For PF? For PNP?
Name two differentiating stains for spitz nevus
S100A6, P16
Sub types of MMP and corresponding antigens