ABO
The H gene elicits the production of a glycosyltransferase that transfers what sugar onto a precursor substance ?
Without this H gene (hh) a patient is said to have what blood type ?
L-fucose
Bombay
Which antigen in the Rh system is most clinically significant and why?
The D antigen is the most clinically significant because it is highly immunogenic and commonly implicated in HDFN.
What is the most important antigen in the Kell system?
The K (K1) antigen is the most clinically significant due to its high immunogenicity.
Once thawed , FFP must be transfused within ____ hours or relabeled as thawed plasma
24
For Autologous donation the donors Hgb should be
11.0 g/dl
for normal donation : 12.5 for women / 13.0 for men
A type O mom has a baby with a type B father . What is the possible genotypes of the baby?
BO or OO ( know genotype vs. Phenotype )
** if asked possible phenotypes : B and O
Rh antibodies are primarily of which immunoglobulin class ?
IgG
What is the clinical relevance of the Duffy blood group?
Duffy antigens act as receptors for Plasmodium vivax; individuals lacking Duffy antigens (Fy[a–b–]) are resistant to P. vivax malaria.
This blood component are indicated in symptomatic anemia, acute blood loss, and to improve oxygen-carrying capacity without causing volume overload.
PRBC
A donor had a positive anti-HAV IgM test 3 months ago. Are they eligible to donate blood ? If not how long are they deferred?
Eligible , no deferral - Hep A is not transmitted by blood transfusion
If that is Hep B or Hep C - permanently deferred ** some discussion if was Hep C before age 11
The gene that must be inherited to form ABO antigens in secretions is :
Se
________ antibodies are formed through immune sensitization, usually following exposure to Rh-positive red cells via blood transfusion or fetomaternal hemorrhage during pregnancy in an Rh-negative individual.
Anti-D
A patient with an M. pneumoniae infection will most likely develop a cold autoantibody with specificity to which antigen?
I
Cryoprecipitate that is has been pooled in an open system must be transfused within ____ hours
4 hours
How long is a patient deferred from donation after having a blood transfusion ?
12 months
A patient who is type A2 would see which results with Anti-A reagent ( mixed with Pt red cells ) , what reaction would you see with mixed with Anti-A1 lectin? What is the Anti-A1 lectin called?
+ with Anti-A
0 with Anti-A1
A1 lectin = Dolichos biflorus
This is a condition where maternal IgG anti-D antibodies cross the placenta and cause immune-mediated destruction of fetal Rh-positive red blood cells, leading to fetal anemia, jaundice, or hydrops fetalis.
hemolytic disease of the fetus and newborn (HDFN)
This phenotype associated with the Kell blood group system is also associated with an X-linked chronic granulomatous disease
McLeod
What is the indication for irradiated blood products?
To prevent transfusion-associated graft-versus-host disease, especially in immunocompromised patients.
How much time must you wait between allogeneic whole blood donations ?
56 days
Put these in order from greatest amount of H substance to least amount of H substance
A2B, A2, O, A1B, A1, B
O >A2>B>A2B>A1>A1B
How is Rh incompatibility prevented?
By administering anti-D immunoglobulin (Rho(D) Ig) to Rh-negative mothers at 28 weeks of gestation and within 72 hours postpartum, or after any sensitizing event.
This blood group system antibodies are often a common cause of delayed Hemolytic transfusion reactions
Kidd
Why are leukoreduced blood products used?
To reduce febrile non-hemolytic transfusion reactions and HLA alloimmunization.
immunization for rubella would result in a temporary deferral of how long?
4 weeks