Goal of RBC Preservation
Approved Anticoagulant-Preservative Solutions for Whole Blood
Additive Preservative Solutions for RBCs
Three Additive Solutions
100
This must be both viable and functional for patients.
What are blood components used for transfusions? pg. 31
100
Lower pH and is lost early in the first few weeks of storage. Max storage of 21 days.
What is acid citrate dextrose (ACD)? pg. 31
100
Added to RBCs after the removal of plasma with/without platelets.
What are additive solutions? pg. 32
100
Manufactured by Baxter Healthcare, contains SAGM.
What is AS-1 Adsol? pg. 32
200
Polyvinly chloride plastic bags
What is the type of bag used to store blood? pg. 31
200
100% more glucose than CPD or 60% more glucose than CPDA-1. Max storage of 35 days.
What is citrate-phosphate-double dextrose (CP2D)? pg. 32
200
From 70-85% to 50-60%
What is the amount the percentage of hematocrit is reduced in RBCs by additives? pg. 32
200
Uses CPD in the primary bag, manufactured by Terumo Corp.
What is AS-5 Optisol? pg. 32
300
As a liquid, between 1 and 6 degrees Celsius.
What is the state and temperature in which blood is stored? pg. 31
300
RBCs become low in 2, 3-DPG by the second week. Max storaged of 21 days.
What is CPD? pg. 31
300
Contains additional nutrient solutions for RBC component.
What is the accessory satellite bag? pg. 32
300
Coupled with CP2D as primary bag anticoagulant-preservative
What is AS-3 Nutricel? pg. 32
400
75%;24 hours
What is the precentage of cells and viability time? pg. 31
400
Helps to stimulate glycolysis. 25% more glucose than CPD. Max storage of 35 days.
What is CPDA-1? pg. 32
400
This causes units to be more viscous and difficult to infuse.
What are high hematocrit RBCs? pg. 32
400
DAILY DOUBLE!!!! 100mL/450mL or 110mL/500mL
What is variation of anticoagulant-preservative solution to blood collection system size? pg. 33
500
Decrease in ATP levels and buildup of lactic acid.
What are causes of loss of RBC viability? pg. 31
500
DAILY DOUBLE!!!! Post-transfusion RBC survival of more than 75% and free hemogloblin less than 1%
What are the FDA requirements for transfused blood? pg. 31
500
Saline, dextrose, and adenine.
What are the three major components of preservative solutions of RBCs? pg. 32
500
42 days
What is the storage time for each additive solution? pg. 32
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