All About ABO
2 major subgroups of Group A
What are A1 and A2?
The most immunogenic antigen in the Rh system
What is the D antigen?
Blood Group System notorious for causing delayed hemolytic transfusion reactions
What is the Kidd System?
Test that detects presence of A, B and D antigens
What is Forward Typing?
Term for the force that repels RBCs from each other in solution
What is Zeta Potential?
Immunoglobulin found in the largest concentration in normal serum
What is IgG?
Type of transfusion reaction indicated by dyspnea, severe headache & pulmonary edema
What is TACO?
Antigen that must be present for individuals to possess A or B antigens on their RBCs
What is the H antigen?
Fisher-Race antigens found in the R2 Weiner Haplotype
What are DcE?
Blood group system that may offer protection against malaria when antigens are not present on the RBCs
What is the Duffy System?
Test that detects antibodies with specificity to RBC antigens
What is Antibody Screen?
Scientific name for Anti-H lectin
What is Ulex Europaeus?
Portion of the antibody that binds to the antigen
What is the Fab Region?
Type of transfusion reaction characterized by sever respiratory distress within 6 hours of transfusion
What is TRALI?
Antibodies expected in serum of patients with Group AB blood
What is no antibodies/neither Anti-A or Anti-B?
Optimal conditions for reaction of Rh system antibodies
What is 37C and AHG? (May also be enhanced by enzymes)
4 Blood Group Systems with IgM antibodies
What are Lewis, Ii, P, MNSs?
Test that identifies specificity of antibodies
Term for the fixed position of a gene on a chromosome
What is a locus/loci?
Type of antibody that is created by the immune system that are directed against "self" antigens
What is an autoantibody?
Step in transfusion investigation that includes comparison of pre and post transfusion specimens for presence of hemolysis
What is the visual check?
Rule that states that healthy individuals possess ABO antibodies to the ABO Blood Group antigens they lack
What is Landsteiner's Rule?
Most common antigen in the Rh System
What is e?
3 Blood Group Systems with IgG antibodies
What are Kell, Duffy & Kidd?
Test used to detect IN VIVO attachment of antibodies to RBCs
What is the Direct Antiglobulin Test (DAT)?
3 basic components of a QA program in blood bank
What are calibration, preventative maintenance & good record keeping practices?
Binding of antibody or complement proteins to a RBC
What is sensitization?
Type of transfusion reaction that specifically involves donor T cells
What is Transfusion Associated Graft Versus Host Disease?
Issue caused by Wharton's Jelly on Cord Blood Cells
What is rouleaux?
Principle reason for determining Rh (D) status of the women during pregnancy
What is D-negative mother should be given Rhogam to prevention formation of anti-D during delivery of a D-positive infant?
Lewis Phenotype of a person that inherits an Le gene, H gene and is a secretor
What is Le(a-b+)?
Test that determines serologic compatibility between donor and patient prior to transfusion
What is crossmatch?
Describe a compatible crossmatch
What is negative through AHG phase and positive with Coombs Control (Check) cells?
Reason for using AHG as a reagent in Blood Bank
What is acts as a bridge molecule to allow for visual hemagglutination of IgG antibodies?
Blood Group System that may cause severe intravascular hemolysis
What is the ABO Blood Group?