Multiple Myeloma
WHAT DOES THE CRAB ACRONYM STAND FOR?
hypercalcemia
renal disease
anemia
bone disorder
What are the two main types of lymphoma?
Hodgkin and Non-Hodgkins
What leukemia is most common in children?
ALL
What are treatments of hyperkalemia?
which ones are potassium shifters and excreters?
shifter (insulin/glucose, albuterol, bicarb)
excreter (lasix,kayexalate, diaylsis)
What do you see on blood smear?
Rouleaux
What are B symptoms?
Fever, night sweats, lymphadenopathy
What emergency is caused by high WBCs in acute leukemia and what is the usual WBC count?
Leukostasis and >100k
Which medication blocks metabolism to uric acid?
Allopurinol
WHAT ARE THE TWO MAIN LABS TO ORDER?
Which type of NHL is often indolent and often widespread at presentation?
Follicular lymphoma
WHAT IS THE TREATMENT FOR LEUKEMIA/LYMPHOMA
EMERGENCIES?
induction therapy
temporize with leukapheresis
allopurinol
What uric acid–lowering drug works on existing uric acid crystals and what is the MOA?
Rasburicase
Oxidizes uric acid to water woluble form
What do you see in the urine?
Bence-Jones Protein
Which virus is associated with some types of Hodgkin lymphoma?
EBV
WHAT LEUKEMIA DO YOU SEE AUER RODS ON SMEAR?
AML
WHAT ARE THE ELECTROLYTE ABNORMALITIES IN TLS?
(name 4)
hyperuricemia
hyperphosphatemia
hyperkalemia
hypocalcemia
What protein spike is typically seen on serum protein electrophoresis (SPEP)?
Monoclonal M
Which lymphoma is bimodal and what do you usually see on biopsy?
Hodgkin and Reed-Sternberg
What is the difference between ALL and AML?
What type of leukemia is most commonly associated with tumor lysis syndrome?
ALL