CPI
What are the due dates for CPI 1?
Jan 1st to April 30th
What is the difference between ALLO and AUTO HCT?
ALLO Uses Donor cells
AUTO Uses own cells
Whats does CIBMTR stand for?
Centers for International Blood and Marrow Transplant Research
What does CAR stand for in CAR-T?
Chimeric Antigen Receptor
What is the current percent for overall forms due category?
95%
Do all Traditional HCT's get Lymphodepletion therapy?
Yes
Before transplant, you get chemotherapy (chemo) and sometimes radiation to destroy the diseased cells and marrow. Then, the healthy cells are given to you.
What is the largest bone in the human body?
The largest bone in the human body is the femur, also known as the thigh bone.
What antigen does CAR-T target?
CD19
which is expressed on the surface of the vast majority of B cells, including B-cell malignancies.
Where can you find CPI guidelines?
CIBMTR Data Management Guide -->
Continuous Process Improvement Program (CPI)
What does HLA stand for and what is it?
Human Leukocyte Antigen
HLA is a protein — or marker — found on most cells in your body
How many bones does an adult have in their Body?
206
Fact:Infants are born with approximately 300 bones, but as they grow some of these bones fuse together.
CAR T-cell therapy is associated with serious side effects, including (3):
Cytokine release syndrome (CRS)
Neurotoxicity
Organ toxicities
How many CPI reporting periods are there?
3
Where do the healthy cells come from?
Healthy blood-forming cells used in transplant can come from 3 sources:
How many chromosomes does the average human have?
46 Chromosomes
Or 23 pairs of chromosomes
Are CAR-T's genetically modified?
Yes:
CARs are genetically engineered cell surface receptors designed to equip a patient’s own T cells with the ability to recognize and bind to antigens (cell surface proteins) found on tumor cells.