Intracellular Compartments and Protein Sorting I
This is a protein with 10 alpha helices that spans the ER membrane.
What is Sec-61?
The most abundant class of phospholipids in the myelin sheath which contains an unusual fatty alcohol that is attached through an ether linkage.
What are plasmalogens?
This protein pinches off the clathrin-coated vesicle.
What is dynamin?
This protein recognizes peroxisomal sorting signal in the cytosol.
What is Pex 5?
This ABC transporter was discovered because it pumps hydrophobic drugs out of cells.
What is the multi-drug resistance (MDR) protein or P-glycoprotein?
Beta barrel proteins get inserted in the outer mitochondrial membrane by this complex.
What is the SAM Complex?
Proteins lacking this will remain in the cytosol.
What is a sorting signal?
These are large vesicles that a cell uses to take up fluids.
What are macropinosomes?
These allow water to move through membranes more rapidly than osmosis.
What are aquaporins?
The two-dimensional fluid structure in which proteins are inserted into lipid bilayers.
What is the fluid mosaic model?
The two resident ER carbohydrates that bind lectins.
What are calnexin and calreticulin?
These are imported as largely unfolded polypeptide chains, facilitated by the translocase of the TOM complex.
What are mitochondrial precursor proteins?
These terminate signaling by inducing GTP hydrolysis.
What are GTPase activating proteins (GAPs)?
P-type pumps, ABC transporters, and V-type pumps are the three main families of this.
What are ATP-driven pumps?
Phosphatidylcholine is mainly found in this layer of the plasma membrane.
What is the outer leaflet?
This mitochondrial protein translocator is involved in inserting synthesized proteins within the matrix into the inner membrane.
What is the OXA Complex?
These are generated when cells are disrupted by homogenization.
What are microsomes?
AP2 acquires a different conformation that exposes binding sites for cargo receptors when it binds to this receptor.
What is phosphoinositide (PIP)?
The period within action potential that limits the repetitive firing rate of the cell to ensure unidirectional propagation.
What is the refractory period?
This describes the change of state in which a lipid bilayer transitions from a liquid form to a 2D rigid crystalline (or gel) state.
What is a phase transition?
This is a random translocator of lipids in membranes and catalyzes the flipping of lipids on the lumenal side of the ER.
What is scramblase?
This is transport between ER, Golgi, and outer membrane.
What is vesicular transport?
These proteins create and change the identity of an organelle.
What are Rab proteins?
This is the signal sequence of amino acids signifying return to ER.
What is KKXX?
This protects transmembrane proteins from the outside world.
What is a glycolipid?