Biology
tumor suppressor genes that help with DNA repair
What is the role of BRCA genes?
20%
What percent of ovarian cancer is associated with a heritable cancer syndrome?
The risk of breast cancer by age 70 in BRCA2 mutation carriers?
What is 49 %
Chromosome 13
Where is the gene for BRCA2 found?
5%
What percent of breast cancer is associated with BRCA 1/2?
The risk of ovarian cancer by age 70 in BRCA2 carriers
What is 10-27 %
Chromosome 17
Where is the gene for BRCA 1 found?
The proportion of individuals who carry a pathogenic variant that develop the disease
What is penetrance?
Risk of breast cancer by age 70 with a BRCA1 mutation
What is 57%?
Other BRCA 1/2 associated cancers
What are prostate, melanoma, pancreatic, possibly uterine- especially papillary serous?
A pathogenic variant identified in a contemporary population that can be traced to a small group of founders isolated by geographic, cultural, or other factors.
What is the founder effect?
Risk of ovarian cancer by age 70 in BRCA1 mutation carriers?
What is 39-46 %