Treatments
the preferred treatment for treating an HER2 negative disease consists of these regimens
what is doxorubicin and cyclophosphamide followed by paclitaxel
this is a major toxicity in the anthracyclines class
what is cardiotoxicity
this type of breast cancer usually has a delayed diagnosis due to it being presumed as cellulitis initial
what is inflammatory
this drug is an alkylating agent that cross links DNA strands therefore decreasing DNA synthesis by preventing cell division
what is cyclophosphamide
This type of cancer is the 2nd leading cause of cancer-related deaths in females
what is breast cancer
the preferred treatment for HER2 positive consists of these 2 regimens
what is paclitaxel and trastuzumab
this CDK 4/6 inhibitor should be used in caution because it can prolong the QTc interval
what is ribociclib
this type of breast cancer has malignant appearing cells within ducts and lobules without actually invading the tissue
what is non-invasive carcinoma (in-situ)
this drug class works by inhibiting DNA and RNA synthesis by inhibiting topoisomerase II and steric obstruction
what is anthracyclines
what percentage of patients will not have risk factors for breast cancer
what is 60%
a common toxicity of anthracyclines is extravasation, the treatment for this is
what is stop the infusion and apply ice
this medication should not be used concurrently with doxorubicin due to an increased risk of cardiomyopathy
what is trastuzumab
this type of breast cancer is associated with heterogeneous groups of tumors that are usually adenocarcinomas and can be classified as IDC or ILC
what is invasive carcinoma
the MOA of this drug class works on microtubules to inhibit the depolymerization of tubulin
what are taxanes
this risk model is used as a tool to determine the % chance of developing breast cancer
what is the GAIL risk model
if a patient is premenopausal at diagnosis, this is the preferred regimen
what is tamoxifen x 5 years +/- ovarian suppression/ablation
endometrial cancer is more common in this selective estrogen receptor modulators
what is tamoxifen
this type of cancer, also known as DCIS, has not fully developed invasive in teh duct
what is ductal carcinoma in situ
this medication binds to the estrogen receptor and down regulates the expression of the receptor
what is Fulvestrant
the use of this drug class along with an anthracycline provides better outcomes
what are taxanes
if a patient is post-menopausal at diagnosis, this is the preferred treatment regimen
what is an aromatase inhibitor x 5 years
due to its potential to cause joint pain and bone density loss, this should be preformed at baseline and every 2 years to monitor bone mineral density
what is a DEXA scan
this type of cancer is a lesion caused by the production of solid cells within a breast lobule
what is lobular carcinoma in situ
exemestane is a steroidal this that works to prevent the conversion of androstenedione to estrone and testosterone to estradiol
what is an aromatase inhibitor
this percent of breast cancers are diagnosed even though there is no family history of breast cancer
what is 85%