iCVA
1 in 4 patients died within ___ year after a COPD hospitalization.
What is 1 year
Breztri is administered via inhalation at this frequency for optimal maintenance treatment
What is 2 inhalataions, 2x day
The year Breztri launched.
2020
The primary endpoint in ETHOS study
Rate of mod/sever COPD exacerbations over 52 weeks
This combination inhaler contains budesonide, glycopyrrolate and Formoterol to manage COPD Symptoms.
Breztri is the ONLY triple therapy to prevent _____ or _____ exacerbations with a 18% reduction vs ICS/LABA.
What is moderate or severe
Breztri should not be used for this type of respiratory event, which requires a quick-relief medication.
What is acute bronchospasm
This test measures the amount of air a person can exhale in one second and is used to diagnose COPD.
Spriometry
The primary endpoint in KRONOS study
FEV1 for Breztri vs BUD/FORM MDI and change from the baseline in morning pre-dose trough or severe COPD exacerbations.
Breztri is prescribed to patients with this chronic respiratory condition characterized by airflow limitation.
What is COPD
The all-cause mortality data was a predefined secondary endpoint in this study.
What is ETHOS
This indicator display has a pointer which will move after every actuation. When nearing the end of the usable inhalations, the pointer is in the yellow zone and should be discarded when in the red zone.
Breztri is delivered using this type of inhaler, which releases a fine mist of medication for inhalation.
What is a pressurized metered-dose inhaler
T or F
The current Gold Report supports the use of ICS/LABA for initial or follow-up treatment of COPD.
False
The Gold Report does not support the use of ICS/LABA for initial follow-up treatment of COPD
Formoterol, one of the components in Breztri, belongs to this class of medications, which helps relax the muscles around the airways.
For every ____ patients treated over a year, Breztri could prevent 1 additional moderate or severe exacerbations vs ICS/LABA?
What is 7
Patients using Breztri should rinse their mouth after each use to prevent this oral fungal infection.
**Bonus if you can explain the process of rinsing the actuator.**
What is thrush (oral candidiasis)
**Remove canister, remove mouthpiece cover, run warm water through mouthpiece for 30 sec and then through the actuator for 30 sec, shake off water, let air dry.
Breztri may cause this cardiovascular side effect, characterized by a faster-than-normal heart rate.
What is tachycardia
1. Majority of patients did not have a history of moderate or severe COPD exacerbations within the past year
2. Mean age: 65 years old
3. approx 90% had moderate or severe COPD
4. 40% current smoker
This corticosteroid in Breztri helps reduce inflammation in the lungs, improving breathing.
On the current ICVA summary page, the three main talking points are...
What is...
52% reduction in mod/sever exacerbations vs LAMA/LABA.
For ever 7 patients treated over a year, Breztri could prevent 1 additional mod/severe exacerbation vs ICS/LABA.
Time to All-Cause Mortality
The process used to mix medicine and propellant, spraying it into the air, to ensure the inhaler is ready to use and delivers the correct dose of medicine
What is Priming
Before 1st use- remove mouthpiece, shake inhaler well and spray 1 test-puff into the air facing away from you. Repeat for a total of 4 test-puffs shaking the inhaler before each test puff.
Patients with this eye condition, involving increased pressure in the eye, should use Breztri with caution.
What is glaucoma
What are the top 3 adverse reactions to Breztri?
What is upper respiratory tract infection, pneumonia, back pain
Glycopyrrolate in Breztri acts as this type of agent, blocking the effect of acetycholine on muscarinic receptors.
What is anticholinergic