Bugs and Drugs

Gaps in Coverage

100

You typically cover for this group of organisms when you are concerned for an aspiration pneumonia

What are anaerobes?

200

Organism that zosyn (piperacillin-tazobactam) covers but unasyn (ampicillin-sulbactam) does not

What is pseudomonas?

300

Per our UTI MAP, you cover a patient with Ceftriaxone empirically pending urine culture, but know that it does not cover this urinary pathogen

What is Enterococcus faecalis? 

(What antibiotic does have coverage?)

400

Ceftaroline has coverage for this organism where Ceftriaxone does not

What is MRSA?

500

We use Ceftriaxone to overcome this mechanism of resistance in CAP

What is beta lactamase producing strep?

Drug of choice

100

Empiric treatment for CAP

What is ampicillin?

200

Empiric treatment for osteomyelitis

What is Cefazolin?

300

Empiric therapy for native valve endocarditis AFTER blood cultures are drawn. Bonus for naming organisms you are covering.

What is vancomycin? staphylococci (MSSA and MRSA), streptococci, and enterococci

400

Initial treatment for first episode of non severe c diff colitis

Oral metronidazole or vancomycin

500

Empiric therapy for meningitis <28 days of age

What is ampicillin and ceftazidime?

Side effects

100

Causes flushing syndrome or infusion reaction

What is vancomycin

200

Known to cause QTc prolongation (give class)

What are macrolides, quinolones?

300

Most common agents to cause TEN/Stevens-Johnson

What are sulfonamides >> penicillins > cephalosporins?

400

Most serious side effect of the aminoglycosides

What is renal failure?

500

Can cause rupture of the Achille's tendon

What are quinolones?

Interactions

100

Often used in conjunction with a penicillin and/or vancomycin for Group A strep infections (STTS), this antibiotic helps control toxin production in bacteria by inhibiting protein synthesis.

What is clindamycin?

200

Treat flushing syndrome with this

What is diphenhydramine

300

Antibiotic choices for a patient with cellulitis who has a severe penicillin allergy

What are Clindamycin, or if severe, Vancomycin?

400

Used for treatment of TB and prosthetic valve endocarditis (and leprosy), this dirty drug interacts with just about everything, including birth control pills

What is rifampin?

500

Used to treat MRSA, can cause serotonin syndrome when given with SSRIs due to its MAOI properties

What is linezolid?

Potpourri

100

Name the SIRS criteria. Bonus for definition of severe sepsis and septic shock.

Temp >38 (100.4) or <36 (96.8) HR>90 RR>20 or PaCO2 <32 mmHg WBC>12,000, <4000, or >10% bands Sepsis=SIRS +source (suspicious or confirmed) severe sepsis= above + organ dysfuntion septic shock= above + hypotension despite fluid resuscitation

200

These cephalosporins cover pseduomonas

What is cefepime and ceftazidime?

300

These are indications for Q12H dosing of Ceftriaxone

What is Meningitis or Enterococcus Endocarditis?

400

Acceptable first line drug for neutropenic fever without culture? (more than one right answer)

What are Cefepime or Meropenem?

500

DRESS syndrome meaning and most commen offenders

What is Drug reaction with eosinophilia and systemic symptoms (DRESS). Antiepileptics, allopurinol, and sulfonamides and vancomycin. Most commonly seen 2-6 weeks after exposure.