Drugs
Bugs
HIV
Name The Drugs!
Mechanisms
100
Which antimicrobial is the most potent CYP3A4 inducer?
Rifampin
100
What is a gram (+) cocci in clusters
Staphylococcus
100
A patient has a CD4 count of 150. Prophylaxis for what opportunistic infection must we initiate?
PCP
100
Name 2 Aminopenicillins
Ampicillin, amoxicillin, augmentin, unasyn
100
This antimicrobial works by blocking DNA gyrase which impairs the supercoiling of DNA
Quinolones
200
Which cephalosporin has the longest half-life?
Ceftriaxone
200
Initially classified as a pseudomonas spp., this gram (-) bacterium can be found colonizing breathing tubes in the ICU and its drug of choice is TMP-SMX
Stenotrophomonas Maltophilia
200
Perform this test prior to initiation of Abacavir
HLA-B*5701
200
Name 2 first generation cephalosporins
Cefazolin, cephalexin, cefadroxil
200
Name 5 classes of antibiotics which work by blocking cell wall synthesis
Penicillins, cephalosporins, carbapenems, Monobactams, Vancomycin
300
This antibiotic covers gram (-) aerobes including pseudomonas however has no activity against gram (+) or anaerobes
Aztreonam
300
This is the most likely organism to elaborate an ESBL
Klebsiella Pneumonia
300
Long-Term toxicity of the NRTI class
Mitochondrial toxicity (lactic acidosis and hepatic steatosis)
300
Name 2 oral third generation cephalosporins
Cefpodoxime (Vantin), Cefixime (Suprax), Cefdinir (Omnicef), Ceftibuten (Cedax), Cefditoren (Spectracef)
300
This class of antibiotics are cationic “detergents” that disrupt bacterial cell membranes of gram (-) bacteria only
Polymixins
400
Use of this antibiotic is associated with Kernicterus when used in neonates or late pregnancy
Sulfonamides and Ceftriaxone
400
AKA Walking Pneumonia
Mycoplasma Pneumonia
400
Name one NRTI that is also active against Hepatitis B
Tenofovir, Lamivudine, and Emtricitabine
400
Which drug is in the glycycline class of antibiotics?
Tigecycline
400
Mutation of dihydropteroate synthase is the resistance mechanism against this class of antibiotics
Sulfonamides
500
ONLY 1st or 2nd generation cephalosporin that crosses the Blood Brain Barrier
Cefuroxime [85%] (not used for meningitis- 3rd gens penetrate better)
500
Which candida species are resistant to fluconazole?
C. Krusei, C. Glabrata
500
This HIV med is known for causing hyperpigmentation of the hands and feet
Emtricitabine
500
Name all oral agents with good MRSA coverage.
Doxycycline, Minocycline, Septra, Clindamycin, Linezolid, Tedizolid
500
Name two resistance mechanisms to penicillins
Production of B-lactamases, Alter PBP, Efflux Mechanism, Porin-deficient mutation- resistance due to decreased permeability
M
e
n
u