Patho/Transmission
Infection of CDI is transmitted by this virulence factor
What is a spore
Common risk factors for developing c. diff. colitis. name 5
What is: abx use, age, illness/immunocompromised, enteral feeding, gastric acid suppression, chemo, IBD
discontinuing stool softeners, laxatives, TF, how many hours before ordering CDI testing.
What is 48 hours
2 common abx used for c. diff. colitis
what is oral vancomycin and dificid
Resistance of C. diff. spores to alcohol and hand sanitizer forces healthcare workers to use this combo. following patient encounter
What is soap and water
It is thought PPI can cause CDI by what mechanism
What is gastric acid suppression
The time at which a stool sample should be collected to test for cure.
What is NEVER
according to UTD this is the recommendation for first line treatment for Non severe c, diff. colitis
What is oral vanco 125mg qid X 10 days
mechanism of action of the 2 main virulence factors of c. diff.
what is toxin A (increased colonic permeability)
What is toxin B (colonic inflammation)
Top abx or classes of abx that contribute to CDI risk
cephalosporins, clindamycin, Augmentin
CDI can occur during, shortly after and rarely up to how many weeks after abx exposure.
What is 10 weeks
first line treatment for severe c. diff infection
po dificid X 10 days
Per healthcare safety network guidelines CDI is hospital acquired if test is positive on/after what hospital day
What is on/after day 4
common signs/symptoms that should be present to consider testing for CDI
What is watery diarrhea, elevated WBC, fever, loss of appetite, abd. pain/tenderness.