Patho/Transmission
Potpourri
Risk Factors
Diagnosis
Treatment

100

C-difficile colonizes the colon and releases these two proteins which cause symptoms.
What are Exotoxins - (A and B)

100

This song won a grammy for Best Album and Best Record of the year(2018).
What is 24K Magic by Bruno Mars

100

Common risk factors for developing C-difficile colitis are these? (name 5)
What is antibiotic use, age, severe illness/immunosuppresion, enteral feeding, gastric acid suppression, cancer, chemo, IBD

100

Findings on XR or endoscopy that are highly suggestive of C-difficile infection?
What is pseudomembraneous colitis. Also, toxic megacolon

100

Two common antibiotics used for C-difficile colitis treatment?
What are vancomycin and metronidazole

200

Infection of C-difficile is transmitted by this virulence factor.
What is a spore

200

He was the Superbowl MVP 2018.
Nick Foles

200

Name 3 of the top 5 antibiotics(class) that cause C-difficile colitis?
What are Ampicillin, amoxicillin, cephalosporins, clindamycin, fluroquinolones

200

The hallmark of symptomatic C-diff colitis is this many stools over this time period.
What is 3 watery, non-bloody stools in a 24 hour time period

200

Dose, frequency, and duration of antibiotic treatment for the two most common antibiotics used in C-diff colitis treatment?
What is PO Flagyl 500mg q8h (or IV) and PO vancomycin 125 qid 10 day course for initial episode

300

Resistance of C-difficile spores to alcohol/hand sanitizer forces healthcare workers to use this combo following patient encounters?
What is soap and water

300

The site of the 2018 Winter Olympics.
What is PyeongChang, South Korea

300

This condition associated w/ c-difficile colitis is linked to rupture of the colon.
What is toxic megacolon

300

Severe disease is described as this.
What is WBC >15,000, Albumin <3, and Creatinine level >1.5x the premorbid level

300

According to up to date, this is the recommendation for first line treatment of nonsevere C-difficile.
What is Vancomycin 125mg PO QID for 10 days

400

More than 80% of the deaths attributable to C-difficile colitis were greater than this age.
What is age 65

400

What is the equation for surface area of a sphere?(regardless of what Dr. Chacey says)

What is 4PiR2

400

It's thought PPIs cause C-diff colitis by this mechanism.
What is gastric acid suppression

400

The time at which a sample should be collected to test for cure.
What is NEVER

400

Treatment of 1st recurrence of C-difficile colitis.
What is Vancomycin 125mg PO QID for 10-14 days, followed by 7 days BID, followed by onece every 2-3 days for 2-8 weeks.

500

Mechanism of action of the two main virulence factors of C-diff?
What is: Enterotoxin A - causes increased colonic permeability Cytotoxin B - causes colonic inflammation

500

Kansas City has 200 of these, officially registered and found across the city.
What are fountains!

500

Antibiotics are given to more than what percentage of hospitalized patients. Within 5%! :)
What is more than 50%.

500

Symptoms of c-difficile colitis occur during therapy, 5-10 days following abx treatment. However, it can occur as rarely up to how many weeks?
What is 10 weeks!

500

Besides Flagyl and Vancomycin, the other treatments for C-difficile infection include these medications.
What is pulsed/tapered vancomyocin, Fidaxomycin, Zinplava(monoclonal Ab), Fecal transplant