Very hard to treat
Shrinks like talking
A NAME to remember
Lets make Adina proud
It is all about Stahl
100
When is depression labelled as treatment resistant?
inadequate response to at least two antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence in clinical practice, with up to 50% to 60% of the patients not achieving adequate response following antidepressant treatment (StAR*D)
100
Most prominent defenses used in Narcissistic personality disorder?
Idealization and devaluation
100
Delusion in which the affected person believes that another person, usually a stranger, high-status or famous person, is in love with him or her.
de Clérambault's syndrome or Erotomania
100
Enzyme implicated in mechanism of action of Disulfiram
Inhibition of Acetaldehyde dehydrogenase resulting in acetaldehyde accumulation and unpleasant effects
100
Serotonin, NE and Dopamine implicated in various forms of depression. Which other Neurotransmitter is implicated in depression in recent studies?
Glutamate - Hyperglutamergic states reducing Neuroplasticity
200
Standard Dictum for psycho pharmacology of OCD
Requires higher doses than recommended for depression and takes longer duration for symptoms to improve Expert recommendations of Sertraline 400 mg, Fluoxetine 120 mg
200
Splitting and Projective Identification are predominant forms of defenses used in
Borderline PD
200
Delusion that a friend, spouse, parent, or other close family member (or pet) has been replaced by an identical-looking impostor
Capgra's Delusion
200
Withdrawal from which drug of abuse causes dysphoria, hypersomnolence, hyperphagia and suicidal behavior
Coccaine
200
Clonidine and Mirtazepine are similar and different in this receptor occupancy
Alpha 2 Clonidine Alpha 2 autoreceptor agonist - Decrease NE/Srt Mirtazepine Alpha 2 antagonist - Increase Sert/NE
300
Use of which experimental drug reduced symptoms of PTSD but caused transient worsening of dissociative symptoms
Ketamine in PTSD Improves extinction with therapy in PTSD
300
The 4 core principles of Psychodynamic psychotherapy are
Therapeutic alliance, transference, counter transference, resistance
300
Delusion that he or she is dead, a major organ is lost from the body or insides are rotting, either figuratively or literally;
Cotard's Delusion
300
What percentage of Dopamine reuptake transporters are usually occupied for experiencing "Coccaine high"
47% Blocking this action of coccaine is the basis for New Coccaine vaccine dAd5GNE (Antibody to coccaine)
300
Which receptor occupancy makes Atypical antipsyhcotics - Atypical?
5HT2A antagonism - resulting in increasing dopamine in basal ganglia and prefrontal cortex
400
First dose effect is seen in which medication class used for which disorder?
Alpha 1 adrenergic blockers Prazosin Reduce dose and try again when stabilized
400
Eye movement desensitization and reprocessing is one of the standard approved treatment for
PTSD
400
Disorder encountered by some individuals visiting or vacationing in Paris or elsewhere in Western Europe characterized by acute delusional states, hallucinations, feelings of persecution (perceptions of being a victim of prejudice, aggression, or hostility from others), derealization, depersonalization, anxiety, and also psychosomatic manifestations such as dizziness, tachycardia, sweating, and others
Paris Syndrome Commonly viewed as cultural shock for Japanese tourists visiting Paris due to shattering of idealized image of Paris held in Japan Average of 12 Japanese people visiting Paris annually have this
400
"Spice" is commonly called as __________ and acts as _____ on _____ receptor
Synthetic Cannabinoid acts as a full agonist at CB-1 receptors whereas Marijuana acts as partial agonist at CB-1 receptors
400
Vortioxetine acts on the following receptors for its mechanism of action.
SERT inhibitor 5HT1A agonist - Reduce sexual dysfunction 5HT1B partial agonist 5HT1D antagonist 5HT7 antagonist - Procognitive 5HT3 antagonist - antinausea, procognitive
500
What do you do when patient starts responding to ECT for Major depression after the 9th treatment?
Continue treatments until patient goes into remission or symptoms plateau Maximum allowed treatment are 20 session as induction High relapse rates following remission
500
4 Core principles and 4 treatment modules of Dialectical Behavioral therapy
DBT is based on four core principles: 1. The primacy of the therapeutic relationship 2. A non-judgmental approach 3. Differentiating between effective and ineffective behaviors 4. Dialectical thinking The Four Treatment Modules of DBT The DBT process involves a progression through four treatment modules: 1. Mindfulness 2. Distress Tolerance 3. Emotion Regulation 4. Interpersonal Effectiveness
500
Delusional belief that a place or location has been duplicated, existing in two or more places simultaneously, or that it has been 'relocated' to another site
Reduplicative Paraamnesia
500
What is Methylene dioxy pyrovalerone?
Commonly known as "Bath salts". 10x more addictive than methamphetamine In animal models, Rats pressed a lever 60 times for a single 0.05 mg/kg dose of methamphetamine. 600 times for equivalent dose of Bath salts
500
Clozapine, olanzapine and mirtazepine cause weight gain by the following receptor activity (Need all three for credit)
5HT2C receptor blockade H1 (histamine) Receptor blockade Muscarinic receptor blockade Lorcaserin acts as a 5HT2C agonist The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety
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